Regenerating optic pathways from the eye to the brain DOI

Bireswar Laha,

Ben K. Stafford,

Andrew D. Huberman

et al.

Science, Journal Year: 2017, Volume and Issue: 356(6342), P. 1031 - 1034

Published: June 9, 2017

Humans are highly visual. Retinal ganglion cells (RGCs), the neurons that connect eyes to brain, fail regenerate after damage, eventually leading blindness. Here, we review research on regeneration and repair of optic system. Intrinsic developmental growth programs can be reactivated in RGCs, neural activity enhance RGC regeneration, functional reformation eye-to-brain connections is possible, even adult brain. Transplantation gene therapy may serve replace or resurrect dead injured retinal neurons. prosthetics restore vision animal models too have practical power clinical setting. Functional restoration sight certain forms blindness likely occur human patients near future.

Language: Английский

Targeting synapse function and loss for treatment of neurodegenerative diseases DOI
Borislav Dejanovic, Morgan Sheng, Jesse E. Hanson

et al.

Nature Reviews Drug Discovery, Journal Year: 2023, Volume and Issue: 23(1), P. 23 - 42

Published: Nov. 27, 2023

Language: Английский

Citations

50
Neuronal maturation and axon regeneration: unfixing circuitry to enable repair DOI
Brett J. Hilton, Jarred M. Griffin, James W. Fawcett

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(10), P. 649 - 667

Published: Aug. 20, 2024

Language: Английский

Citations

18
Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration DOI Creative Commons
Alexandra B. Byrne,

Trent Walradt,

Kathryn E. Gardner

et al.

Neuron, Journal Year: 2014, Volume and Issue: 81(3), P. 561 - 573

Published: Jan. 16, 2014

Language: Английский

Citations

159
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis DOI Creative Commons

Sarah Huntwork‐Rodriguez,

Bei Wang, Trent A. Watkins

et al.

The Journal of Cell Biology, Journal Year: 2013, Volume and Issue: 202(5), P. 747 - 763

Published: Aug. 26, 2013

Neurons are highly polarized cells that often project axons a considerable distance. To respond to axonal damage, neurons must transmit retrograde signal the nucleus enable transcriptional stress response. Here we describe mechanism by which this is propagated through injury-induced stabilization of dual leucine zipper-bearing kinase (DLK/MAP3K12). After neuronal insult, specific sites throughout length DLK underwent phosphorylation c-Jun N-terminal kinases (JNKs), have been shown be downstream targets pathway activity. These events resulted in increased abundance via reduction ubiquitination, was mediated E3 ubiquitin ligase PHR1 and de-ubiquitinating enzyme USP9X. Abundance turn controlled levels JNK signaling apoptosis. Through feedback mechanism, ubiquitin–proteasome system able provide an additional layer regulation generate global cellular response localized external insults.

Language: Английский

Citations

154
Regenerating optic pathways from the eye to the brain DOI

Bireswar Laha,

Ben K. Stafford,

Andrew D. Huberman

et al.

Science, Journal Year: 2017, Volume and Issue: 356(6342), P. 1031 - 1034

Published: June 9, 2017

Humans are highly visual. Retinal ganglion cells (RGCs), the neurons that connect eyes to brain, fail regenerate after damage, eventually leading blindness. Here, we review research on regeneration and repair of optic system. Intrinsic developmental growth programs can be reactivated in RGCs, neural activity enhance RGC regeneration, functional reformation eye-to-brain connections is possible, even adult brain. Transplantation gene therapy may serve replace or resurrect dead injured retinal neurons. prosthetics restore vision animal models too have practical power clinical setting. Functional restoration sight certain forms blindness likely occur human patients near future.

Language: Английский

Citations

148