New insights into the function of Rab GTPases in the context of exosomal secretion DOI Creative Commons
Lionel Blanc, Michel Vidal

Small GTPases, Journal Year: 2017, Volume and Issue: 9(1-2), P. 95 - 106

Published: Jan. 31, 2017

In the last two decades, extracellular vesicle-mediated communication between cells has become a major field in cell biology. However, function of vesicles is far from clear, especially due to disparity released by cells. Basically, one must consider budding plasma membrane (ectosomes) and upon fusion an endosomal multivesicular compartment (exosomes). Moreover, even for exosomes, we report discuss here possibility that different routes regulated specific Rab GTPases might produce exosomes having various biologic functions.

Language: Английский

Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer DOI Open Access
Guy Berchem, Muhammad Zaeem Noman,

Manon Bosseler

et al.

OncoImmunology, Journal Year: 2015, Volume and Issue: 5(4)

Published: June 24, 2015

Tumor-derived microvesicles (TD-MVs) are key mediators which shed by cancer cells and can sensitize neighboring in the tumor microenvironment. TD-MVs extracellular vesicles composed of exosomes MVs promote invasion metastasis. Intratumoral hypoxia is an integral component all solid tumors. The relationship between hypoxic tumor-shed NK-mediated cytotoxicity remains unknown. In this paper, we reported that derived from qualitatively differ those normoxic cells. Using multiple models, showed inhibit more NK cell function as compared to MVs. Hypoxic package two immunosuppressive factors involved impairment natural killer (NK) against different vitro vivo. We following their uptake cells, transfer TGF-β1 decreasing surface expression activating receptor NKG2D, thereby inhibiting function. MicroRNA profiling revealed presence high levels miR-210 miR-23a TD-MVs. demonstrated operates additional immunomosuppressive factor, since it directly targets CD107a To our knowledge, first study show secreting educate decrease antitumor immune response. This highlights existence a novel mechanism suppression mediated further improves understanding mechanisms prevailing

Language: Английский

Citations

285
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer DOI Open Access
Ellen C. de Heer, Mathilde Jalving, Adrian L. Harris

et al.

Journal of Clinical Investigation, Journal Year: 2020, Volume and Issue: 130(10), P. 5074 - 5087

Published: Sept. 1, 2020

Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis metabolic rewiring are well-established drivers of breast aggressiveness, therapy resistance, poor prognosis. Targeting HIF its downstream targets in metabolism has been unsuccessful so far clinical setting, with major unresolved challenges residing target selection, development robust biomarkers for response prediction, understanding harnessing escape mechanisms. This Review discusses pathophysiological role HIFs, angiogenesis, targeting these features patients cancer. Rational therapeutic combinations, especially immunotherapy endocrine therapy, seem most promising exploitation intricate interplay cells tumor microenvironment.

Language: Английский

Citations

277
Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins DOI
Kalpana Deepa Priya Dorayappan,

Ross Wanner,

John Wallbillich

et al.

Oncogene, Journal Year: 2018, Volume and Issue: 37(28), P. 3806 - 3821

Published: April 11, 2018

Language: Английский

Citations

269
Role of hypoxia-induced exosomes in tumor biology DOI Creative Commons

Chuchu Shao,

Fengming Yang,

Suyu Miao

et al.

Molecular Cancer, Journal Year: 2018, Volume and Issue: 17(1)

Published: Aug. 11, 2018

Hypoxia is a major regulator of angiogenesis and always influences the release exosomes in various types tumors. The present review aimed to assess role hypoxia-induced tumor biology. relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, other similar terms. Recent studies have shown that cancer cells produce more under hypoxic conditions than do parental normoxic conditions. secretion function could be influenced by hypoxia cancer. Hypoxia-induced play critical roles angiogenesis, invasion, metastasis, immune system. These findings provide new insights into complex networks underlying cellular genomic regulation response might novel specific targets for future therapies.

Language: Английский

Citations

268
New insights into the function of Rab GTPases in the context of exosomal secretion DOI Creative Commons
Lionel Blanc, Michel Vidal

Small GTPases, Journal Year: 2017, Volume and Issue: 9(1-2), P. 95 - 106

Published: Jan. 31, 2017

In the last two decades, extracellular vesicle-mediated communication between cells has become a major field in cell biology. However, function of vesicles is far from clear, especially due to disparity released by cells. Basically, one must consider budding plasma membrane (ectosomes) and upon fusion an endosomal multivesicular compartment (exosomes). Moreover, even for exosomes, we report discuss here possibility that different routes regulated specific Rab GTPases might produce exosomes having various biologic functions.

Language: Английский

Citations

267