Investigation of Low‐Current Direct Stimulation for Rehabilitation Treatment Related to Muscle Function Loss Using Self‐Powered TENG System

Advanced Science, Journal Year: 2019, Volume and Issue: 6(14)

Published: June 12, 2019

Abstract Muscle function loss is characterized as abnormal or completely lost muscle capabilities, and it can result from neurological disorders nerve injuries. The currently available clinical treatment to electrically stimulate the diseased muscles. Here, a self‐powered system of stacked‐layer triboelectric nanogenerator (TENG) multiple‐channel epimysial electrode directly muscles demonstrated. Then, two challenges regarding direct TENG stimulation are further investigated. For first challenge improving low‐current efficiency, found that optimum efficiency be achieved by conducting systematic mapping with electrode. second stability. It force output generated TENGs more stable than using conventional square wave enveloped high frequency stimulation. With modelling in vivo measurements, confirmed factors account for long pulse duration low current amplitude. waveform effectively avoid synchronous motoneuron recruitment at electrodes reduce fluctuation. after investigating these challenges, believed could used rehabilitative therapeutic purpose treatment.

Language: Английский

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Wireless, battery-free subdermally implantable photometry systems for chronic recording of neural dynamics

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(6), P. 2835 - 2845

Published: Jan. 23, 2020

Significance Monitoring neuronal activity with cell specificity in freely behaving animal models can yield insights into underpinning operating mechanisms of the brain. Dynamics genetically targeted populations be recorded through calcium indicators; however, current tools for such measurements are only available tethers or large and heavy externalized head stages, potential to influence behaviors test subjects limit experimental paradigms simple two-dimensional arenas. Here, we introduce highly miniaturized, wireless, battery-free, subdermally implantable photometry systems that bypass these limitations enable chronic recording neural dynamics ethologically relevant environments no impact on subject behavior. This technology has broad utility neuroscience research fundamentally new experiments simultaneous behavior studies.

Language: Английский

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Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications

Frontiers in Cellular Neuroscience, Journal Year: 2019, Volume and Issue: 13

Published: Oct. 23, 2019

Understanding how neuronal activity patterns in the brain correlate with complex behavior is one of primary goals modern neuroscience. Chemical transmission major way communication between neurons; however, traditional methods detection neurotransmitter and neuromodulator transients mammalian lack spatiotemporal precision. Modern fluorescent biosensors for neurotransmitters neuromodulators allow monitoring chemical vivo millisecond precision single cell resolution. Changes biosensor brightness occur upon binding can be detected using fiber photometry, stationary microscopy miniaturized head-mounted microscopes. Biosensors expressed animal adeno-associated viral vectors, their cell-specific expression achieved Cre-recombinase expressing animals. Although initially were represented by glutamate biosensors, nowadays GABA, acetylcholine, glycine, norepinephrine dopamine are available as well. In this review, we overview functioning principles existing intensiometric ratiometric provide brief insight into variety neurotransmitter-binding proteins from bacteria, plants eukaryotes including G-protein coupled receptors, which may serve scaffolds. We next describe a workflow development biosensors. then discuss advanced setups functional imaging awake freely moving conclude providing application examples studies single-neuron

Language: Английский

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Emerging Soft Conductors for Bioelectronic Interfaces

Advanced Functional Materials, Journal Year: 2019, Volume and Issue: 30(29)

Published: Nov. 29, 2019

Abstract Bidirectional interfacing between electrodes and biological systems has enabled diagnostics therapeutics in modern medicine; however, the inherent dissimilarity soft, ion‐rich, dynamic tissues rigid, dry, static electronic hinders establishment of effective reliable bioelectronic interfaces. In past decade, scope flexible/stretchable electronics been broadened into bioelectronics owing to need implementation various biocompatible soft conductors. Herein, basic requirements for construction both epidermal implantable interfaces utilizing materials are discussed, most recent progress development conductors, which customized interface with skin other tissues, summarized. An outlook remaining obstacles is provided possible strategies facilitate technological advances also outlined.

Language: Английский

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Recent Advances in Flexible Inorganic Light Emitting Diodes: From Materials Design to Integrated Optoelectronic Platforms

Advanced Optical Materials, Journal Year: 2018, Volume and Issue: 7(2)

Published: Sept. 20, 2018

Abstract The emergence of high‐performance materials for flexible inorganic light emitting diodes (ILEDs) provides the foundations a broad range compelling, unconventional systems, from deformable displays and lighting sources to wearable implantable bioelectronics with diagnostic therapeutic capabilities. Interdisciplinary progress in synthetic methods, device designs, mechanical layouts, assembly techniques over past decade enables ILEDs remarkable operating characteristics even under extreme modes deformation. This review summarizes recent advances this field, emphasis on unique properties underlying physics first several sections. subsequent content highlights examples system‐level integration into advanced optoelectronic platforms that would be difficult or impossible achieve conventional approaches. Miniaturized, biomedical tools optical modulation neural activity at target sites conformable, skin‐mounted electronics sensing visualization physiological parameters real time provide some most directions.

Language: Английский

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