What have we really learned from functional connectivity in clinical populations?

NeuroImage, Journal Year: 2021, Volume and Issue: 242, P. 118466 - 118466

Published: Aug. 10, 2021

Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool for probing functional abnormalities in clinical populations due to promise approach across conceptual, technical, and practical levels. With an already vast steadily accumulating neuroimaging literature on neurodevelopmental, psychiatric, neurological diseases disorders which FC is primary measure, we aim here provide high-level synthesis major concepts that have arisen from findings manner cuts different conditions sheds light overarching principles. We highlight allowed us discover ubiquity intrinsic networks virtually all brains clarify typical patterns neurodevelopment over lifespan. This understanding maturation with age provided important benchmarks against evaluate divergent early life degeneration late life. turn led insight many are associated complex, distributed, network-level changes brain, opposed solely focal abnormalities. further emphasize role studies played supporting dimensional studying transdiagnostic symptoms enhancing multimodal characterization prediction trajectory symptom progression conditions. unprecedented opportunity offered by probe where function could not be easily studied otherwise, such consciousness. Lastly, suggest high priority areas future research acknowledge critical barriers use methods, particularly those related artifact removal, data denoising feasibility contexts.

Language: Английский

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The early origins and the growing popularity of the individual-subject analytic approach in human neuroscience

Current Opinion in Behavioral Sciences, Journal Year: 2021, Volume and Issue: 40, P. 105 - 112

Published: March 19, 2021

Language: Английский

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Overlooked Tertiary Sulci Serve as a Meso-Scale Link between Microstructural and Functional Properties of Human Lateral Prefrontal Cortex

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(10), P. 2229 - 2244

Published: Jan. 21, 2021

Understanding the relationship between neuroanatomy and function in portions of cortex that perform functions largely specific to humans such as lateral prefrontal (LPFC) is major interest systems cognitive neuroscience. When considering neuroanatomical–functional relationships LPFC, shallow indentations known tertiary sulci have been unexplored. Here, by implementing a multimodal approach manually defining 936 neuroanatomical structures 72 hemispheres (in both males females), we show subset these overlooked serve meso-scale link microstructural (myelin content) functional (network connectivity) properties human LPFC individual participants. For example, posterior middle frontal sulcus (pmfs) with three components differ their myelin content, resting-state connectivity profiles, engagement across meta-analyses 83 tasks. Further, generating profiles content cortical depths for each pmfs component surrounding gyrus (MFG) shows gyral sulcal MFG greater deeper compared superficial layers than components. These findings support classic, yet unconsidered theory may landmarks association cortices, well modern neuroscience proposing hierarchy LPFC. As there growing need computational tools automatically define throughout cortex, share probabilistic maps field. SIGNIFICANCE STATEMENT Lateral critical are thought be other mammals. However, fine-scale hominoid remain elusive. structures, which unexplored history, surprisingly markers anatomical organization theoretical, methodological, developmental, evolutionary implications improved understanding not only but also cortices more broadly. Finally, ignite new questions regarding how morphological features neglected contribute human-specific aspects cognition.

Language: Английский

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Heritability of individualized cortical network topography

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(9)

Published: Feb. 23, 2021

Significance The widespread use of population-average cortical parcellations has provided important insights into broad properties human brain organization. However, the size, location, and spatial arrangement regions comprising functional networks can vary substantially across individuals. Here, we demonstrate considerable heritability in both size organization individual-specific network topography cortex. Genetic factors had a regionally variable influence on organization, such that but not topography, was greater unimodal relative to heteromodal cortices. These data suggest may provide an avenue understand genetic basis variation cognition behavior.

Language: Английский

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Striving toward translation: strategies for reliable fMRI measurement

Trends in Cognitive Sciences, Journal Year: 2021, Volume and Issue: 25(9), P. 776 - 787

Published: June 14, 2021

Language: Английский

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