Molecular Biology of the Cell,
Journal Year:
2025,
Volume and Issue:
36(5)
Published: May 1, 2025
Like
eukaryotes,
bacteria
and
archaea
rely
on
intracellular
organelles
to
manage
biological
activities.
Despite
their
prevalence,
the
understanding
of
diversity
these
molecular
mechanisms
governing
function
remain
limited.
In
this
review,
we
examine
potential
genomics
metagenomics
augment
classical
approaches
for
study
discovery
microbial
organelles.
First,
highlight
how
intimate
interplay
between
model
system
studies
have
been
critical
in
illuminating
function,
diversity,
ancient
evolutionary
origins
lipid-bounded
magnetosome
magnetotactic
bacteria.
We
next
discuss
central
role
open
genome
databases
mechanistic
identification
characterization
protein-bounded
encapsulin
with
novel
roles
sulfur
metabolism
other
cellular
processes.
Finally,
focus
mostly
uncultured
Asgard
superphylum,
whose
metagenomes
are
challenging
our
views
organelle
evolution
eukaryogenesis.
Molecular Biology and Evolution,
Journal Year:
2021,
Volume and Issue:
38(9), P. 3531 - 3542
Published: June 22, 2021
The
relationship
between
the
three
domains
of
life-Archaea,
Bacteria,
and
Eukarya-is
one
Biology's
greatest
mysteries.
Current
favored
models
imply
two
ancestral
domains,
Bacteria
Archaea,
with
eukaryotes
originating
within
Archaea.
This
type
has
been
supported
by
recent
description
Asgardarchaeota,
closest
prokaryotic
relatives
eukaryotes.
However,
there
are
many
problems
associated
any
scenarios
implying
that
originated
from
including
genome
mosaicism,
phylogenies,
cellular
organization
their
character.
By
contrast,
all
eukaryogenesis
fail
to
consider
relevant
discoveries:
detection
membrane
coat
proteins,
phagocytosis-related
processes
in
Planctomycetes,
which
among
bacteria
most
developed
endomembrane
system.
Consideration
these
often
overlooked
features
others
found
Planctomycetes
related
suggest
an
evolutionary
model
based
on
a
single
domain.
In
this
model,
proximity
Asgard
is
not
rejected
but
instead,
considered
as
diverging
away
common
ancestor
instead
way
toward
eukaryotic
ancestor.
domain
solves
ambiguities
ones
domains.
single-domain
better
suited
explain
origin
evolution
life,
blurring
distinctions
them.
Support
for
well
opportunities
it
presents
only
reinterpreting
previous
results,
also
planning
future
experiments,
explored.
Microbiology and Molecular Biology Reviews,
Journal Year:
2023,
Volume and Issue:
87(4)
Published: Nov. 29, 2023
SUMMARY
In
this
hypothesis
article,
we
explore
the
origin
of
eukaryotic
nucleus.
doing
so,
first
look
afresh
at
nature
defining
feature
cell
and
its
core
functions—emphasizing
utility
seeing
nucleoplasm
cytoplasm
as
distinct
regions
a
common
compartment.
We
then
discuss
recent
progress
in
understanding
evolution
from
archaeal
bacterial
ancestors,
focusing
on
phylogenetic
experimental
data
which
have
revealed
that
many
machines
with
nuclear
activities
counterparts.
addition,
review
literature
describing
biology
representatives
TACK
Asgardarchaeaota
-
closest
known
living
relatives
eukaryotes.
Finally,
bringing
these
strands
together,
propose
model
for
nucleus
explains
much
current
data,
including
predictions
can
be
used
to
put
test.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 279 - 279
Published: Feb. 13, 2025
Eukaryotic
actin
filaments
play
a
central
role
in
numerous
cellular
functions,
with
each
function
relying
on
the
interaction
of
specific
actin-binding
proteins.
Understanding
mechanisms
that
regulate
these
interactions
is
key
to
uncovering
how
perform
diverse
roles
at
different
locations.
Several
distinct
classes
regulatory
have
been
proposed
and
experimentally
supported.
However,
vary
their
nature
hierarchy.
For
instance,
some
operate
under
control
others,
highlighting
hierarchical
relationships.
Additionally,
while
certain
are
fundamental
ubiquitous
across
eukaryotes,
others
lineage-specific.
Here,
we
emphasize
importance
functional
significance
following
mechanisms:
biochemical
regulation
nucleators,
ATP
hydrolysis-dependent
aging
filaments,
thermal
fluctuation-
mechanical
strain-dependent
conformational
changes
cooperative
induced
by
Molecular Biology of the Cell,
Journal Year:
2025,
Volume and Issue:
36(5)
Published: May 1, 2025
Like
eukaryotes,
bacteria
and
archaea
rely
on
intracellular
organelles
to
manage
biological
activities.
Despite
their
prevalence,
the
understanding
of
diversity
these
molecular
mechanisms
governing
function
remain
limited.
In
this
review,
we
examine
potential
genomics
metagenomics
augment
classical
approaches
for
study
discovery
microbial
organelles.
First,
highlight
how
intimate
interplay
between
model
system
studies
have
been
critical
in
illuminating
function,
diversity,
ancient
evolutionary
origins
lipid-bounded
magnetosome
magnetotactic
bacteria.
We
next
discuss
central
role
open
genome
databases
mechanistic
identification
characterization
protein-bounded
encapsulin
with
novel
roles
sulfur
metabolism
other
cellular
processes.
Finally,
focus
mostly
uncultured
Asgard
superphylum,
whose
metagenomes
are
challenging
our
views
organelle
evolution
eukaryogenesis.
