Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: July 1, 2022

Abstract Background One of the most malignant tumors in men is prostate cancer that still incurable due to its heterogenous and progressive natures. Genetic epigenetic changes play significant roles development. The RNA molecules with more than 200 nucleotides length are known as lncRNAs these factors do not encode protein. They regulate gene expression at transcriptional, post-transcriptional levels. LncRNAs vital biological functions cells pathological events, hence their undergoes dysregulation. Aim review role alterations development emphasized here. Therefore, were chosen for this purpose level interaction other signaling networks progression examined. Key scientific concepts aberrant has been well-documented rate tumor regulated via affecting STAT3, NF-κB, Wnt, PI3K/Akt PTEN, among molecular pathways. Furthermore, radio-resistance chemo-resistance features cells. Overexpression tumor-promoting such HOXD-AS1 CCAT1 can result drug resistance. Besides, induce immune evasion upregulating PD-1. Pharmacological compounds quercetin curcumin have applied targeting lncRNAs. siRNA tool reduce thereby suppressing progression. Prognosis diagnosis clinical course be evaluated by exosomal lncRNA-p21 investigated serum patients a reliable biomarker.

Language: Английский

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Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma

Molecular Therapy, Journal Year: 2022, Volume and Issue: 30(6), P. 2342 - 2353

Published: Feb. 19, 2022

Type 2 diabetes mellitus (DM2) is associated closely with non-alcoholic fatty liver disease (NAFLD) by affecting lipid metabolism, which may lead to steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma (HCC). N6-methyladenosine (m6A) RNA methylation an important epigenetic regulation for gene expression related HCC development. We developed a new NAFLD model oriented from DM2 mouse, spontaneously progressed histological features of NASH, high incidence. By sequencing, protein methylated immunoprecipitation (MeRIP)-qPCR analysis, we found that enhanced ACLY SCD1 in this human samples was due excessive m6A modification, but not elevation mature SREBP1. Moreover, targeting METTL3/14 vitro increases level as well triglyceride cholesterol production accumulation droplets. sequencing analysis revealed overexpressed METTL14 binds mRNA alters their pattern. Our findings demonstrate mouse provides study platform DM2-related reveals unique epitranscriptional regulating mechanism metabolism via m6A-modified SCD1.

Language: Английский

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The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(4), P. 513 - 534

Published: April 1, 2024

Language: Английский

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Functional states of myeloid cells in cancer

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 490 - 504

Published: March 1, 2023

Language: Английский

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Ferroptosis: A flexible constellation of related biochemical mechanisms

Molecular Cell, Journal Year: 2023, Volume and Issue: 83(7), P. 1030 - 1042

Published: March 27, 2023

Language: Английский

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