Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior DOI Creative Commons
Man Yong Han,

Deyang Zeng,

Wei Tan

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 159 - 173

Published: April 3, 2024

Brain-derived neurotrophic factor is a key in stress adaptation and avoidance of social behavioral response. Recent studies have shown that brain-derived expression stressed mice brain region–specific, particularly involving the corticolimbic system, including ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, hippocampus. Determining how participates processing different regions will deepen our understanding psychopathology. In this review, we discuss regulation stress-sensitive closely related to pathophysiology depression. We focused on associated molecular pathways neural circuits, with special attention factor–tropomyosin receptor kinase B signaling pathway area–nucleus accumbens dopamine circuit. determined stress-induced alterations levels are likely nature, severity, duration stress, especially above-mentioned system. Therefore, BDNF might be biological indicator regulating stress-related processes various regions.

Language: Английский

Pinocembrin Inhibits P2X4 Receptor–Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats DOI

Runan Yang,

Jingjian Yang,

Zijing Li

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(12), P. 7119 - 7133

Published: Sept. 10, 2022

Language: Английский

Citations

22
Enhanced TARP-γ8-PSD-95 coupling in excitatory neurons contributes to the rapid antidepressant-like action of ketamine in male mice DOI Creative Commons

Shi-Ge Xue,

Jin‐Gang He, Lingli Lu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 2, 2023

Ketamine produces rapid antidepressant effects at sub-anesthetic dosage through early and sustained activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), however, the exact molecular mechanism still remains unclear. Transmembrane AMPAR regulatory protein-γ8 (TARP-γ8) is identified as one auxiliary subunits, which controls assemblies, surface trafficking gating AMPARs. Here, we show that ketamine rescues both depressive-like behaviors decreased AMPARs-mediated neurotransmission by recruitment TARP-γ8 postsynaptic sites in ventral hippocampus stressed male mice. Furthermore, are abolished selective blockade TARP-γ8-containing or uncoupling from PSD-95. Overexpression reverses chronic stress-induced attenuation neurotransmission. Conversely, knockdown excitatory neurons prevents ketamine.

Language: Английский

Citations

13
Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels DOI
Hui Ma, Jinfeng Li,

Xin Qiao

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 45(4), P. 704 - 713

Published: Dec. 14, 2023

Language: Английский

Citations

12
Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice DOI Creative Commons
Ren-Wen Han, Ziyi Zhang, Jiao Chen

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 24, 2024

Abstract Understanding how distinct functional circuits are coordinated to fine-tune mood and behavior is of fundamental importance. Here, we observe that within the dense projections from basolateral amygdala (BLA) bed nucleus stria terminalis (BNST), there two functionally opposing pathways orchestrated enable contextually appropriate expression anxiety-like behaviors in male mice. Specifically, anterior BLA neurons predominantly innervate anterodorsal BNST (adBNST), while their posterior counterparts send massive fibers oval (ovBNST) with moderate adBNST. Optogenetic activation inputs oppositely regulated activity adBNST behaviors, via disengaging engaging inhibitory ovBNST-to-adBNST microcircuit, respectively. Importantly, exhibited synchronized but opposite responses both anxiolytic anxiogenic stimuli, partially due mutual inhibition different they receive. These findings reveal synergistic interactions between BLA-to-BNST for anxiety ongoing environmental demands.

Language: Английский

Citations

4
Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior DOI Creative Commons
Man Yong Han,

Deyang Zeng,

Wei Tan

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 159 - 173

Published: April 3, 2024

Brain-derived neurotrophic factor is a key in stress adaptation and avoidance of social behavioral response. Recent studies have shown that brain-derived expression stressed mice brain region–specific, particularly involving the corticolimbic system, including ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, hippocampus. Determining how participates processing different regions will deepen our understanding psychopathology. In this review, we discuss regulation stress-sensitive closely related to pathophysiology depression. We focused on associated molecular pathways neural circuits, with special attention factor–tropomyosin receptor kinase B signaling pathway area–nucleus accumbens dopamine circuit. determined stress-induced alterations levels are likely nature, severity, duration stress, especially above-mentioned system. Therefore, BDNF might be biological indicator regulating stress-related processes various regions.

Language: Английский

Citations

4