The Modus Operandi of Hydrogen Sulfide(H2S)-Dependent Protein Persulfidation in Higher Plants DOI Creative Commons
Francisco J. Corpas, Salvador González‐Gordo, María A. Muñoz‐Vargas

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(11), P. 1686 - 1686

Published: Oct. 26, 2021

Protein persulfidation is a post-translational modification (PTM) mediated by hydrogen sulfide (H2S), which affects the thiol group of cysteine residues from target proteins and can have positive, negative or zero impact on protein function. Due to advances in proteomic techniques, number potential targets identified higher plants, are affected this PTM, has increased considerably. However, its precise biological function needs be evaluated at experimental level purified order identify specific cysteine(s) residue(s) affected. It also cellular redox given interactions among different oxidative modifications (oxiPTMs), such as S-nitrosation, glutathionylation, sulfenylation, S-cyanylation S-acylation, affect groups. This review aims provide an updated comprehensive overview important physiological role exerted acts mechanism protection against irreversible oxidation.

Language: Английский

Nitric oxide and hydrogen sulfide: an indispensable combination for plant functioning DOI
Vipul Mishra, Pooja Singh, Durgesh Kumar Tripathi

et al.

Trends in Plant Science, Journal Year: 2021, Volume and Issue: 26(12), P. 1270 - 1285

Published: Aug. 18, 2021

Language: Английский

Citations

126
Phytomelatonin: A key regulator of redox and phytohormones signaling against biotic/abiotic stresses DOI Creative Commons
Shoaib Khan, Sulaiman Ahmed,

Aziz ul Ikram

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 64, P. 102805 - 102805

Published: June 30, 2023

Plants being sessile in nature, are exposed to unwarranted threats as a result of constantly changing environmental conditions. These adverse factors can have negative impacts on their growth, development, and yield. Hormones key signaling molecules enabling cells respond rapidly different external internal stimuli. In plants, melatonin (MT) plays critical role the integration various signals activation stress-response networks develop defense mechanisms plant resilience. Additionally, tackle stress-induced alteration cellular redox equilibrium by regulating expression hemostasis-related genes proteins. The purpose this article is compile summarize scientific research pertaining MT's effects plants' resilience biotic abiotic stresses. Here, we summarized that MT exerts synergistic effect with other phytohormones, for instance, ethylene, jasmonic acid, salicylic activates defense-related against phytopathogens. Furthermore, interacts secondary messengers like Ca2+, nitric oxide, reactive oxygen species regulate network. This interaction triggers transcription alleviate stress-related responses plants. Hence, synergic diverse hormones demonstrates phytomelatonin's importance influencing multiple contribute harsh factors.

Language: Английский

Citations

46
Hydrogen sulfide mechanism of action in plants; from interaction with regulatory molecules to persulfidation of proteins DOI

Shirin Mohammadbagherlou,

Elaheh Samari,

Mostafa Sagharyan

et al.

Nitric Oxide, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Hydrogen sulfide signaling in plant adaptations to adverse conditions: molecular mechanisms DOI Creative Commons
Ángeles Aroca, Jing Zhang,

Yanjie Xie

et al.

Journal of Experimental Botany, Journal Year: 2021, Volume and Issue: 72(16), P. 5893 - 5904

Published: May 24, 2021

Hydrogen sulfide (H2S) is a signaling molecule that regulates critical processes and allows plants to adapt adverse conditions. The molecular mechanism underlying H2S action relies on its chemical reactivity, the most-well characterized persulfidation, which involves modification of protein thiol groups, resulting in formation persulfide groups. This causes change function, altering catalytic activity or intracellular location inducing important physiological effects. cannot react directly with thiols but instead can oxidized cysteine residues; therefore, H2O2 through sulfenylation required for persulfidation. A comparative study performed this review reveals 82% identity between sulfenylome persulfidome. With regard abscisic acid (ABA) signaling, widespread evidence shows an interconnection ABA plant response environmental stress. Proteomic analyses have revealed persulfidation several proteins involved network shown triggered ABA. In guard cells, complex interaction has also been described, specific components seems be mechanism.

Language: Английский

Citations

75
Thiol-based Oxidative Posttranslational Modifications (OxiPTMs) of Plant Proteins DOI Creative Commons
Francisco J. Corpas, Salvador González‐Gordo, Marta Rodríguez-Ruiz

et al.

Plant and Cell Physiology, Journal Year: 2022, Volume and Issue: 63(7), P. 889 - 900

Published: March 21, 2022

Abstract The thiol group of cysteine (Cys) residues, often present in the active center protein, is particular importance to protein function, which significantly determined by redox state a protein’s environment. Our knowledge different thiol-based oxidative posttranslational modifications (oxiPTMs), compete for specific groups, has increased over last 10 years. principal oxiPTMs include S-sulfenylation, S-glutathionylation, S-nitrosation, persulfidation, S-cyanylation and S-acylation. role each oxiPTM depends on cellular state, turn homeostasis under either optimal or stressful conditions. Under such conditions, metabolism molecules as glutathione, NADPH (reduced nicotinamide adenine dinucleotide phosphate), nitric oxide, hydrogen sulfide peroxide can be altered, exacerbated and, consequently, outside cell’s control. This review provides broad overview these physiological unfavorable regulate function target proteins.

Language: Английский

Citations

56
Hydrogen Sulfide, Ethylene, and Nitric Oxide Regulate Redox Homeostasis and Protect Photosynthetic Metabolism under High Temperature Stress in Rice Plants DOI Creative Commons
Harsha Gautam, Mehar Fatma, Zebus Sehar

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1478 - 1478

Published: July 28, 2022

Rising temperatures worldwide due to global climate change are a major scientific issue at present. The present study reports the effects of gaseous signaling molecules, ethylene (200 µL L-1; 2-chloroethylphosphonic acid; ethephon, Eth), nitric oxide (NO; 100 µM sodium nitroprusside; SNP), and hydrogen sulfide (H2S; 200 hydrosulfide, NaHS) in high temperature stress (HS) tolerance, whether or not H2S contributes NO-induced thermo-tolerance photosynthetic protection rice (Oryza sativa L.) cultivars, i.e., Taipei-309, Rasi. Plants exposed an HS 40 °C for six h per day 15 days caused reduction biomass, associated with decreased photosynthesis leaf water status. High increased oxidative by increasing content peroxide (H2O2) thiobarbituric acid reactive substance (TBARS) leaves. These molecules status, osmolytes, antioxidants, plants under non-stress stress. However, effect was more conspicuous than NO H2S. application scavenger hypotaurine (HT) reversed on HS. This supports findings that ameliorating Eth SNP involved Thus, presence can enhance while also protecting plant photosynthesis.

Language: Английский

Citations

44
Emerging Chemical Biology of Protein Persulfidation DOI Creative Commons
Thibaut Vignane, Miloš R. Filipović

Antioxidants and Redox Signaling, Journal Year: 2023, Volume and Issue: 39(1-3), P. 19 - 39

Published: June 8, 2023

Significance: Protein persulfidation (the formation of RSSH), an evolutionarily conserved oxidative posttranslational modification in which thiol groups cysteine residues are converted into persulfides, has emerged as one the main mechanisms through hydrogen sulfide (H2S) conveys its signaling. Recent Advances: New methodological advances persulfide labeling started unraveling chemical biology this and role (patho)physiology. Some key metabolic enzymes regulated by persulfidation. RSSH levels important for cellular defense against injury, they decrease with aging, leaving proteins vulnerable to damage. Persulfidation is dysregulated many diseases. Critical Issues: A relatively new field signaling protein still unanswered questions: mechanism(s) transpersulfidation identification "protein persulfidases," improvement methods monitor changes identify targets, understanding controls (patho)physiological functions. Future Directions: Deep mechanistic studies using more selective sensitive techniques will provide high-resolution structural, functional, quantitative, spatiotemporal information on dynamics help better how H2S-derived affects structure function health disease. This knowledge could pave way targeted drug design a wide variety pathologies. Antioxid. Redox Signal. 39, 19-39.

Language: Английский

Citations

38
Recent advances and mechanistic interactions of hydrogen sulfide with plant growth regulators in relation to abiotic stress tolerance in plants DOI

Bisma Hilal,

Tanveer Ahmad Khan,

Qazi Fariduddin

et al.

Plant Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 196, P. 1065 - 1083

Published: March 1, 2023

Language: Английский

Citations

29
Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response DOI
Bo He, Zhe Zhang,

Zhao Huang

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 209, P. 115444 - 115444

Published: Feb. 1, 2023

Language: Английский

Citations

27
Sulfide promotes tolerance to drought through protein persulfidation in Arabidopsis DOI Creative Commons
Ana Jurado-Flores, Ángeles Aroca, Luís C. Romero

et al.

Journal of Experimental Botany, Journal Year: 2023, Volume and Issue: 74(15), P. 4654 - 4669

Published: May 6, 2023

Abstract Hydrogen sulfide (H2S) is a signaling molecule that regulates essential plant processes. In this study, the role of H2S during drought was analysed, focusing on underlying mechanism. Pretreatments with before imposing plants substantially improved characteristic stressed phenotypes under and decreased levels typical biochemical stress markers such as anthocyanin, proline, hydrogen peroxide. also regulated drought-responsive genes amino acid metabolism, repressed drought-induced bulk autophagy protein ubiquitination, demonstrating protective effects pretreatment. Quantitative proteomic analysis identified 887 significantly different persulfidated proteins between control plants. Bioinformatic analyses more in revealed most enriched biological processes were cellular response to oxidative peroxide catabolism. Protein degradation, abiotic responses, phenylpropanoid pathway highlighted, suggesting importance persulfidation coping stress. Our findings emphasize promoter enhanced tolerance drought, enabling respond rapidly efficiently. Furthermore, main alleviating reactive oxygen species accumulation balancing redox homeostasis highlighted.

Language: Английский

Citations

26