ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer DOI

Liankun Song,

Vyvyan Nguyen, Jun Xie

et al.

Molecular Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 23(6), P. 854 - 863

Published: Feb. 28, 2024

Docetaxel has been the standard first-line chemotherapy for lethal metastatic prostate cancer (mPCa) since 2004, but resistance to docetaxel treatment is common. The molecular mechanisms of remain largely unknown and could be amenable interventions that mitigate resistance. We have recently discovered several docetaxel-resistant mPCa cell lines exhibit lower uptake cellular copper uniquely express higher levels a exporter protein ATP7B. Knockdown ATP7B by silencing RNAs (siRNA) sensitized cells growth-inhibitory apoptotic effects docetaxel. Importantly, deletions in human tissues predict significantly better survival patients after their first than those with wild-type (P = 0.0006). In addition, disulfiram (DSF), an FDA-approved drug alcohol dependence, combination copper, enhanced vivo antitumor xenograft tumor model. Our analyses also revealed DSF engaged decrease COMM domain-containing 1 (COMMD1), S-phase kinase-associated 2 (Skp2), clusterin markedly increase expression cyclin-dependent kinase inhibitor (p21/WAF1). Taken together, our results indicate copper-dependent nutrient vulnerability through improving therapeutic efficacy

Language: Английский

A Self-Immobilizing Photoacoustic Probe for Ratiometric In Vivo Imaging of Cu(II) in Tumors DOI Creative Commons
Qian Sun, Huan Liu, Ying Yang

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(4), P. 260 - 266

Published: March 3, 2025

Cu(II) ions play a critical role in tumor growth and metastasis, making vivo high-resolution imaging of crucial for understanding its pathophysiology. However, designing suitable molecular probes this purpose remains challenging. Herein, we report the development photoacoustic probe specific tumors. This utilizes β-galactoside as targeting group incorporates unique self-immobilization strategy. Upon β-galactosidase-mediated cleavage, generates reactive quinone methide intermediate that covalently binds to intracellular proteins, enabling selective accumulation. The exhibits ratiometric response with high selectivity over other biological species. In vitro studies demonstrated efficacy research provides valuable insights into tumorigenesis may facilitate diagnostic therapeutic approaches cancer.

Language: Английский

Citations

0
Copper-based nanoplatforms and their role in cancer therapy DOI
José I. García-Peiro, Javier Bonet‐Aleta,

José L. Hueso

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216542 - 216542

Published: March 13, 2025

Language: Английский

Citations

0
Activity-based trapping for multiplex imaging illuminates the hidden role of endogenous formaldehyde in proinflammatory signaling DOI
Yuan Pan,

Xingguang Liang,

Tianruo Shen

et al.

Published: March 1, 2025

Language: Английский

Citations

0
Capturing copper to inhibit inflammation DOI
Christopher J. Chang, Donita C. Brady

Nature Chemical Biology, Journal Year: 2023, Volume and Issue: 19(8), P. 937 - 939

Published: July 13, 2023

Language: Английский

Citations

10
ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer DOI

Liankun Song,

Vyvyan Nguyen, Jun Xie

et al.

Molecular Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 23(6), P. 854 - 863

Published: Feb. 28, 2024

Docetaxel has been the standard first-line chemotherapy for lethal metastatic prostate cancer (mPCa) since 2004, but resistance to docetaxel treatment is common. The molecular mechanisms of remain largely unknown and could be amenable interventions that mitigate resistance. We have recently discovered several docetaxel-resistant mPCa cell lines exhibit lower uptake cellular copper uniquely express higher levels a exporter protein ATP7B. Knockdown ATP7B by silencing RNAs (siRNA) sensitized cells growth-inhibitory apoptotic effects docetaxel. Importantly, deletions in human tissues predict significantly better survival patients after their first than those with wild-type (P = 0.0006). In addition, disulfiram (DSF), an FDA-approved drug alcohol dependence, combination copper, enhanced vivo antitumor xenograft tumor model. Our analyses also revealed DSF engaged decrease COMM domain-containing 1 (COMMD1), S-phase kinase-associated 2 (Skp2), clusterin markedly increase expression cyclin-dependent kinase inhibitor (p21/WAF1). Taken together, our results indicate copper-dependent nutrient vulnerability through improving therapeutic efficacy

Language: Английский

Citations

3