OTORHINOLARYNGOLOGY,
Journal Year:
2023,
Volume and Issue:
unknown, P. 91 - 100
Published: Jan. 1, 2023
The
structure
of
the
hearing
organ
combines
simplicity
and
depth,
remaining
in
many
issues
subject
active
scientific
research.
ontogenesis
this
exquisite
mechanism
is
regulated
by
complex
still
incompletely
understood
mechanisms.
technological
tools
modern
biomedical
science
allow
not
only
to
study,
but
also
work
at
cellular
molecular
level.
In
article,
we
review
data
on
realism
restoring
population
human
auditory
receptors
promising
ways
solve
problem.
addition,
offer
an
answer
a
fundamental
question
–
why,
with
small
number
relatively
simply
arranged
receptor
cells
inner
ear,
their
self-restored.
Key
words:
spiral
organ,
stem
cells,
progenitors,
impairments,
regeneration,
bioprosthetics,
bioengineering.
Clinical and Experimental Otorhinolaryngology,
Journal Year:
2024,
Volume and Issue:
17(1), P. 1 - 14
Published: Jan. 19, 2024
Cochlear
hair
cells
convert
sound
into
electrical
signals
that
are
relayed
via
the
spiral
ganglion
neurons
to
central
auditory
pathway.
Hair
vulnerable
damage
caused
by
excessive
noise,
aging,
and
ototoxic
agents.
Non-mammals
can
regenerate
lost
mitotic
regeneration
direct
transdifferentiation
of
surrounding
supporting
cells.
However,
in
mature
mammals,
damaged
not
replaced,
resulting
permanent
hearing
loss.
Recent
studies
have
uncovered
mechanisms
which
sensory
organs
non-mammals
neonatal
mammalian
cochlea
cells,
outlined
possible
why
this
ability
declines
rapidly
with
age
mammals.
Here,
we
review
similarities
differences
between
avian,
zebrafish,
cell
regeneration.
Moreover,
discuss
advances
limitations
their
potential
applications
human
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 21, 2024
The
Myc
family
of
proto-oncogenes
is
a
key
node
for
the
signal
transduction
external
pro-proliferative
signals
to
cellular
processes
required
development,
tissue
homoeostasis
maintenance,
and
regeneration
across
evolution.
tight
regulation
synthesis
activity
essential
restricting
its
oncogenic
potential.
In
this
review,
we
highlight
central
role
that
plays
in
animal
kingdom
(from
Cnidaria
echinoderms
Chordata)
how
could
be
employed
unlock
regenerative
potential
non-regenerative
tissues
humans
therapeutic
purposes.
Mastering
fine
balance
harnessing
ability
promote
transcription
without
triggering
oncogenesis
may
open
door
many
exciting
opportunities
development
wide
array
diseases.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(12), P. 3347 - 3347
Published: Dec. 18, 2023
Up
to
1.5
billion
people
worldwide
suffer
from
various
forms
of
hearing
loss,
with
an
additional
1.1
at
risk
insults
such
as
increased
consumption
recreational
noise-emitting
devices
and
ageing.
The
most
common
type
impairment
is
sensorineural
loss
caused
by
the
degeneration
or
malfunction
cochlear
hair
cells
spiral
ganglion
nerves
in
inner
ear.
There
currently
no
cure
for
loss.
However,
emerging
frontier
technologies
gene,
drug
cell-based
therapies
offer
hope
effective
cure.
In
this
review,
we
discuss
current
therapeutic
progress
treatment
We
describe
evaluate
major
approaches
being
applied
summarize
key
trials
studies.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 10, 2024
Cyclooxygenase
2
(COX-2)
and
5-lipoxygenase
(5-LOX)
are
overexpressed
in
gastric
cancer
cells,
the
dual
inhibitors
of
which
exhibit
potential
against
metastasis
invasion
with
fewer
side
effects.
To
discover
targeting
COX-2
5-LOX,
we
conducted
ultrafiltration
enrichment
calculation
to
screen
candidates
quaternary
alkaloids
(QAs)
from
Frontiers in Surgery,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 17, 2025
Background
The
field
of
otolaryngology
has
achieved
remarkable
progress
over
the
past
decade
due
to
technological
advancements
and
interdisciplinary
integration.
Understanding
research
trends
hotspots
is
essential
drive
further
innovation
development.
Methods
A
comprehensive
search
was
conducted
on
Web
Science
November
22,
2024,
identify
top
1,000
most-cited
publications
from
2014
2024.
Data
were
analyzed
using
GraphPad
Prism
v8.0.2,
CiteSpace
(6.2.4R),
VOSviewer
(1.6.18)
visualize
networks.
Results
annual
publication
volume
in
decreased
after
2014,
with
United
States
dominating
both
count
citation
frequency.
Influential
journals
prominent
authors
identified,
areas
expanded
beyond
traditional
clinical
management
fields.
Chronic
rhinosinusitis,
olfactory
dysfunction,
machine
learning
emerged
as
key
hotspots.
Conclusion
Otolaryngology
made
significant
across
multiple
domains.
Future
should
focus
integrating
artificial
intelligence
into
practice,
fostering
collaborations,
advancing
precision
medicine
translational
research.
These
efforts
will
be
critical
for
addressing
emerging
challenges
capitalizing
new
opportunities
field.
Communications Biology,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: April 5, 2025
T
cells
have
been
reported
to
play
critical
roles
in
preventing
of
microsporidia
dissemination.
However,
there
and
functions
each
subset
remain
unclear.
Here
the
study,
we
performed
a
thorough
analysis
murine
splenic
T-cell
response
via
single-cell
RNA
sequencing
during
E.
cuniculi
infection.
We
demonstrated
that
Type
I
helper
(Th1)
cells,
follicular
(Tfh)
effector
CD8
+
proliferating
were
activated
expanded
after
Activated
Th1
Tfh
presented
significantly
upregulated
gene
expression
Ifng
Il21,
respectively.
A
subcluster
with
high
Csf1
was
detected
Subsets
markedly
enriched
cytotoxic-function
related
genes
such
as
Gzma
Gzmb,
whereas
some
active
proliferation-function
Mki67
Stmn1.
Other
subsets
including
NK
Myb+
γδ
Cxcr6+
also
analyzed
this
study
yet
no
expansion
observed.
In
summary,
our
findings
provide
in-depth
comprehensive
insights
into
responses
infection,
which
will
be
valuable
for
further
investigations.
Immunological Reviews,
Journal Year:
2025,
Volume and Issue:
331(1)
Published: April 17, 2025
Abstract
Thymic
mimetic
cells
are
hybrids
of
medullary
thymic
epithelial
and
diverse
peripheral
cell
types.
They
important
for
the
imposition
self‐tolerance
perform
other
functions
similar
to
those
their
counterparts.
Following
early
histological
observations
“misplaced”
stromal
in
thymi
from
multiple
species,
were
first
molecularly
investigated
mice.
Recent
studies
have
characterized
humans
zebrafish
with
high‐resolution.
Many
types
conserved
across
although
specialized
subtypes
as
well
variable
frequencies
levels
specialization
also
apparent.
Features
human
repertoire,
such
expanded
nature
muscle
potential
implications
myasthenia
gravis
similarity
tuft
carcinomas,
hint
at
relevance
disease.
Here
we
review
what
is
known
about
organisms.
We
discuss
pressures
shaping
composition
repertoire
within
highlight
therapeutic
applications
