Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 11, 2024
Abstract A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity focal deep stimulation with fMRI coverage entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, subsequent restoration responsiveness by electrical thalamus, investigate loss consciousness impacts distributed patterns structure-function organisation across scales. We report that activity under anaesthesia increasingly constrained structure scales, coinciding anaesthetic-induced collapse multiple dimensions hierarchical cortical organisation. These signatures are observed different anaesthetics, they reversed recovery behavioural markers arousal. No such effects were upon stimulating ventral lateral demonstrating specificity. Overall, identify consistent orchestrated specific thalamic nuclei.
Language: Английский
Citations
13
Neuroinformatics, Journal Year: 2024, Volume and Issue: unknown
Published: April 3, 2024
Language: Английский
Citations
10
Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110314 - 110314
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Psychopharmacology, Journal Year: 2023, Volume and Issue: 38(1), P. 56 - 67
Published: Oct. 28, 2023
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that induces rapid and transient altered state of consciousness when inhaled or injected via bolus administration. Its marked novel subjective effects make DMT powerful tool for the neuroscientific study preliminary results show its potential role in treating mental health conditions. In within-subjects, placebo-controlled study, we investigated method administration involving injection paired with constant-rate infusion, goal extending experience. Pharmacokinetic parameters estimated from plasma data previous intravenous were used to derive dose regimens necessary keep subjects steady levels immersion into experience over an extended period 30 min, four consisting loading slow-rate infusion tested eleven healthy volunteers (seven male, female, mean age ± SD = 37.09 8.93 years). The present effective stable tolerable fashion. While maintained active anxiety ratings remained low heart rate habituated within 15 indicating psychological physiological safety DMT. Plasma concentrations increased consistently starting 10 min administration, whereas plateaued desired state, suggesting development acute tolerance Taken together, these findings demonstrate effectiveness continuous IV laying groundwork further this basic clinical research.
Language: Английский
Citations
18
Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(9), P. 1096 - 1110
Published: Aug. 5, 2024
Abstract Effective interventions for neuropsychiatric disorders may work by rebalancing the brain’s functional hierarchical organization. Here we directly investigated effects of two different serotonergic pharmacological on brain hierarchy in major depressive disorder a two-arm double-blind phase II randomized controlled trial comparing psilocybin therapy (22 patients) with escitalopram (20 patients). Patients received either 2 × 25 mg oral psilocybin, three weeks apart, plus six daily placebo (‘psilocybin arm’) or 1 (10–20 mg; ‘escitalopram arm’). Resting-state magnetic resonance imaging scans were acquired at baseline and after second dose ( NCT03429075 ). The mechanisms captured generative effective connectivity, estimated from whole-brain modeling resting state each session patient. Hierarchy was determined these sessions using measures directedness trophic levels which captures cycle structure, stability percolation. results showed that created significantly reconfigurations dynamics differential, opposite statistical effect responses. Furthermore, use machine learning revealed significant differential reorganization before treatments. Machine also able to predict treatment response an accuracy 0.85 ± 0.04. Overall, demonstrate ways depression. This suggests hypothesis could be closely linked breakdown regions orchestrating top hierarchy.
Language: Английский
Citations
8
Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(10), P. 1640 - 1651
Published: May 28, 2024
Abstract Adolescence is a time of rapid neurodevelopment and the endocannabinoid system particularly prone to change during this time. Cannabis commonly used drug with high prevalence use among adolescents. The two predominant phytocannabinoids are Delta-9-tetrahydrocannabinol (THC) cannabidiol (CBD), which affect system. It unknown whether period development makes adolescents more or less vulnerable effects cannabis on brain-network connectivity, CBD may attenuate THC. Using fMRI, we explored impact vaporized (placebo, THC: 8 mg/75 kg, THC + CBD: kg & 24 CBD) resting-state networks in groups semi-regular users (usage frequency between 0.5 3 days/week), consisting 22 (16–17 years) young adults (26–29 matched for frequency. caused reductions within-network connectivity default mode (F[2,88] = 3.97, P 0.022, η² 0.018), executive control 18.62, < 0.001, 0.123), salience 12.12, 0.076), hippocampal 14.65, 0.087), limbic striatal 16.19, 0.102) compared placebo. Whole-brain analysis showed significantly disrupted functional cortical regions control, salience, hippocampal, did not counteract THC’s further reduced both within whole brain. While age-related differences were observed, there no interactions age group treatment any brain network. Overall, these results challenge assumption that can make safer, as (and some cases potentiated them); furthermore, they show causes similar disruption adolescent adult
Language: Английский
Citations
7
eLife, Journal Year: 2024, Volume and Issue: 12
Published: July 18, 2024
How is the information-processing architecture of human brain organised, and how does its organisation support consciousness? Here, we combine network science a rigorous information-theoretic notion synergy to delineate ‘synergistic global workspace’, comprising gateway regions that gather synergistic information from specialised modules across brain. This then integrated within workspace widely distributed via broadcaster regions. Through functional MRI analysis, show correspond brain’s default mode network, whereas broadcasters coincide with executive control network. We find loss consciousness due general anaesthesia or disorders corresponds diminished ability integrate information, which restored upon recovery. Thus, coincides breakdown integration work contributes conceptual empirical reconciliation between two prominent scientific theories consciousness, Global Neuronal Workspace Integrated Information Theory, while also advancing our understanding supports through information.
Language: Английский
Citations
7
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 11, 2024
Background Due to their potential impact on mood and wellbeing there has been increasing interest in the of serotonergic psychedelics such as N,N-dimethyltryptamine (DMT) treatment major depressive disorder (MDD). Aim The aim Part A this study was evaluate safety, tolerability, pharmacokinetics (PK) pharmacodynamic (PD) profile escalating doses SPL026 (DMT fumarate) psychedelic-naïve healthy participants determine a dose for administration patients with MDD subsequent Phase 2a part trial (Part B: not presented manuscript). Methods In 1, randomized, double-blind, placebo-controlled, parallel-group, single dose-escalation trial, were randomized placebo ( n = 8) or four different [9, 12, 17 21.5 mg intravenously (IV)] 6 each dose) together psychological support from 2 therapy team members. PK acute (immediately following dosing experience) psychometric measures [including mystical experience questionnaire (MEQ), ego dissolution inventory (EDI), intensity rating visual analogue scale (IRVAS)] determined. Additional endpoints measured longer-term change baseline days 8, 15, 30 90. These included Warwick Edinburgh mental Spielberger’s state-trait anxiety inventory. Results well tolerated, an acceptable safety profile, no serious adverse events. There some evidence correlation between maximum plasma concentration increased IRVAS, MEQ, EDI scores. trends are likely require confirmation larger sample size. Using analysis PD, results, most provide intense, tolerated experience. Conclusion Based data obtained given 2-phase IV infusion over 10 min (6 mg/5 15.5 min) selected be taken into B (to future Clinical registration: www.clinicaltrials.gov , identifier NCT04673383; https://www.clinicaltrialsregister.eu 2020-000251-13; https://www.isrctn.com/ ISRCTN63465876.
Language: Английский
Citations
6
Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(4), P. 401 - 416
Published: Feb. 23, 2024
Language: Английский
Citations
6
Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(8)
Published: Aug. 1, 2024
Abstract Breathwork is an understudied school of practices involving intentional respiratory modulation to induce altered state consciousness (ASC). We simultaneously investigate the phenomenological and neural dynamics breathwork by combining Temporal Experience Tracing, a quantitative methodology that preserves temporal subjective experience, with low-density portable EEG devices. Fourteen novice participants completed course up 28 sessions—of 20, 40, or 60 min—in days, yielding neurophenomenological dataset 301 sessions. Using hypothesis-driven data-driven approaches, we found “psychedelic-like” experiences were associated increased Lempel-Ziv complexity during breathwork. Exploratory analyses showed aperiodic exponent power spectral density—but not oscillatory alpha power—yielded similar associations. Non-linear features, like exponent, neurally map both multidimensional composite positive experiences, aspects psychedelic-like experience states such as high bliss.
Language: Английский
Citations
6