Development of Sustainable Insecticide Candidates for Protecting Pollinators: Insight into the Bioactivities, Selective Mechanism of Action and QSAR of Natural Coumarin Derivatives against Aphids

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(47), P. 18359 - 18374

Published: Nov. 15, 2023

Plants employ abundant toxic secondary metabolites to withstand insect attack, while pollinators can tolerate some natural defensive compounds. Coumarins, as promising green alternatives chemical insecticides, possess wide application prospects in the crop protection field. Herein, bioactivities of 30 coumarin derivatives against Aphis gossypii were assessed and revealed that 6-methylcoumarin exhibited potent aphicidal activity aphids but displayed no toxicity honeybees. Additionally, using biochemical, bioinformatic, molecular assays, we confirmed action mode was by inhibiting acetylcholinesterase (AChE). Meanwhile, functional assays difference site, which located Lys585 aphid AChE (equivalent Val548 honeybee AChE), principal reason for being safe pollinators. This site further validated mutagenesis data, uncovered how unique selective over or mammalian AChE. Furthermore, a 2D-QSAR model established, revealing central structural feature H3m, offers guidance future design more work provides sustainable strategy take advantage analogues pest management protecting nontarget

Language: Английский

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Quantifying the contributions of road and air traffic to ambient ultrafine particles in two urban communities

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123892 - 123892

Published: March 29, 2024

Language: Английский

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Long term exposure to PM_2.5 chemical components associated with prevalence of cardiovascular diseases in China

The Innovation Medicine, Journal Year: 2024, Volume and Issue: 2(3), P. 100077 - 100077

Published: Jan. 1, 2024

<sec>Introduction<p>Ambient fine particulate matter pollution (PM_2.5) has been widely associated with cardiovascular disease (CVD). However, less is known about the contribution of different chemical components PM_2.5 to CVD using a nationally representative sample in China. </p></sec><sec>Methods<p>A older adults was recruited from 31 provinces, municipalities, or autonomous regions China by fourth national Urban and Rural Elderly Population Survey 2015. We estimated annual average concentrations its five dust-free (black carbon [BC], organic [OM], sulphate [<inline-formula><tex-math id="M1">$ {{\text{SO}_{\text{4}}^{\text{2-}} }}$</tex-math></inline-formula>], nitrate id="M2" color="#3e88b5">${ {\text{N}\text{O}}_{\text 3}^{\text -} }$</tex-math></inline-formula>], ammonium id="M3">$ { {\text{N}\text{H}}_{\text 4}^{\text +} }$</tex-math></inline-formula>]) at geocoded residential addresses spatial resolution 10×10 km bilinear interpolation. Logistic regression models were constructed estimate associations between prevalence self-reported CVD, potential reducible fractions further counterfactual analyses. </p></sec><sec>Results<p>A total 220,425 participants mean age 69.73 years, 52.24% females, 6.08% minor ethnicity included study, which 55,837 (25.3%) reported having CVD. An interquartile range (IQR) increment significantly elevated risk prevalence. The odds ratios 1.254 (95% CI: 1.235-1.275, IQR: 7.11 µg/m³) for <inline-formula><tex-math id="M4">$ {\text{N}\text{O}}_{\text3}^{\text-} $</tex-math></inline-formula>, 1.197 1.178-1.216, 4.35 id="M5">$ 1.187 1.173-1.202, 5.34 OM, 1.122 1.107-1.137, 0.97 BC, 1.106 1.089-1.123, 4.67 id="M6">$ {\text{S}\text{O}}_{\text 2-} $</tex-math></inline-formula>. stronger those than 70 years. </p></sec><sec>Conclusions<p> Our study suggests that long-term exposure could increase Future air guidelines target reducing specific may help alleviate burden CVD.</p></sec>

Language: Английский

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Air pollution we breathe: Assessing the air quality and human health impact in a megacity of Southeast Asia

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 942, P. 173403 - 173403

Published: June 5, 2024

Language: Английский

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Copper-enriched automotive brake wear particles perturb human alveolar cellular homeostasis

Particle and Fibre Toxicology, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 13, 2025

Abstract Background Airborne fine particulate matter with diameter < 2.5 μm (PM2.5), can reach the alveolar regions of lungs, and is associated over 4 million premature deaths per year worldwide. However, source-specific consequences PM2.5 exposure remain poorly understood. A major, but unregulated source car brake wear, which exhaust emission reduction measures have not diminished. Methods We used an interdisciplinary approach to investigate brake-wear upon lung cellular homeostasis using diesel PM as a comparator. This involved RNA-Seq analyse global transcriptomic changes, metabolic analyses glycolytic reprogramming, mass spectrometry determine composition, reporter assays provide mechanistic insight into differential effects. Results identified from copper-enriched non-asbestos organic, ceramic pads inducing greatest oxidative stress, inflammation, pseudohypoxic HIF activation (a pathway implicated in diseases air pollution exposure, including cancer, pulmonary fibrosis), well perturbation metabolism, metal compared wear low- or semi-metallic pads, also, importantly, PM. Compositional chelator that effects were driven by copper. Conclusions demonstrate here may perturb more than Our findings potential differences effects, only for non-exhaust vs PM, also amongst different sources has implications our understanding health road vehicle-associated More broadly, illustrate importance composition on highlighting need targeted legislation protect public health.

Language: Английский

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The effect of air pollution (PM2.5) and green spaces availability on healthy ageing in the Western Pacific Region

Journal of Global Health Economics and Policy, Journal Year: 2025, Volume and Issue: 5

Published: April 23, 2025

Background While air pollution, specifically PM2.5 particulate concentration, is a leading contributor to an estimated 4.2 million premature deaths annually, access urban green spaces vital in mitigating the detrimental effects of pollution and enhancing public health. Yet, interplay space availability on health-adjusted life expectancy (HALE) unclear Western Pacific Region (WPRO) characterised by rapid population ageing high burden pollution-related deaths. Methods This study employed population-based approach analysed data from 21 countries using databases WHO United Nations. One-way ANOVA linear regression analysis were used evaluate influence concentration factors different year groups HALE at age 60. Results All WPRO exceeded WHO’s recommended annual mean quality guideline 5 μg/m³. For all region, had strong significantly negative 60, while moderately positive However, extent association varied across various region. Conclusions The findings indicate that more ambitious control policies are warranted, particularly high-polluting nations. Simultaneously, increasing through planning environmental preservation appears be important complementary strategy for promoting healthy WPRO. require action, income-specific strategies critical countries.

Language: Английский

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Studying the Relationship Between Coal Consumption and Health of Rural Residents: Evidence from China

Environmental Health Insights, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 1, 2025

Due to the remoteness of rural areas, impact environmental pollution on residents’ health has not received adequate attention. This study examined relationship between coal consumption and status in areas China 2005 2021. We explored air caused by combustion residents provided associated countermeasures. The annual number medical visits was evaluated via multiple regression, Pearson correlation Granger causality tests were used evaluate relationships changes mortality rates various diseases areas. results revealed that for domestic use had a significant ( P < .001) positive effect frequency treatment, whereas this at production end. Significant correlations existed increased 7 out 10 main diseases. Causal identified due urogenital system nervous empirical suggest gradual promotion clean energy replacement with electricity natural gas should reduce probability exposure emitted from residents. Related coal-consuming be screened regularly effectively protect safety

Language: Английский

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Neurotoxic chemistry: Unraveling the chemical mechanisms connecting environmental toxin exposure to neurological disorders

Journal of Integrated Science and Technology, Journal Year: 2025, Volume and Issue: 13(3)

Published: Jan. 7, 2025

The environmental pollution poses a serious global health risk, contributing to high morbidity and mortality rates. Neurological disorders, such as Alzheimer's, Parkinson's, Schizophrenia, ALS, Huntington's disease, are increasingly prevalent characterized by both structural functional abnormalities in neurons of the brain spinal cord. Understanding neuro-impact toxins is crucial for developing effective prevention intervention strategies. This review article investigates complex interactions between neurological health, focusing on their role development progression neurodegenerative neuropsychiatric disorders. Key mechanisms include oxidative stress, mitochondrial dysfunction, and, disruption neurotransmitter systems. It highlights pathways through which these exert effects, presents epidemiological evidence linking toxin exposure discusses potential public implications. By elucidating connections, paper aims enhance understanding determinants health.

Language: Английский

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The Role of Air Pollution and Olfactory Dysfunction in Alzheimer’s Disease Pathogenesis

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 246 - 246

Published: Jan. 20, 2025

The escalating issue of air pollution contributes to an alarming number premature fatalities each year, thereby posing a significant threat global health. focus recent research has shifted towards understanding its potential association with neurodegenerative diseases, specifically Alzheimer’s disease (AD). AD is recognised for characteristic deposition toxic proteins within the brain, leading steady deterioration cognitive capabilities, memory failure, and, ultimately, death. There burgeoning evidence implying that may be contributing factor this protein build up, intensifying course AD. It been demonstrated olfactory system, responsible smell perception and processing, acts as gateway airborne pollutants inflict brain damage. This review aims elucidate relationship between pollution, deterioration, Additionally, highlight mechanisms through which might instigate development role system in pathogenesis. Moreover, diverse model systems employed exploring correlation, public health policy ramifications, prospective directions future will discussed.

Language: Английский

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Evaluation of Particulate Emissions During Braking Tests in Technical–Mechanical Overhaul Workshops in Armenia-Quindío (Colombia)

Environments, Journal Year: 2025, Volume and Issue: 12(2), P. 39 - 39

Published: Jan. 27, 2025

Brake testing of vehicles is one the most important tests performed in technical–mechanical overhaul workshops (TMOWs). During this test, fine and ultrafine particles are emitted, exposing workers to health risks. A mixed descriptive observational study was conducted 10 TMOWs Armenia (Colombia), where particle sampling using NIOSH 0600 method. One third samples were sent for SEM analysis determine their chemical composition size. The average occupational exposure 24.31 mg/m3, almost times higher than threshold limit value particles. range sizes from 1.12 54.33 µm, with an arithmetic mean 14.89 µm. size ranged 198 nm 798 nm. Traces components refractory materials, fiberglass, wollastonite, thermoplastics, among others, typical brake pads, found. This research allows us confirm presence TMOW tests. Therefore, we recommend improvement actions based on epidemiological surveillance programs respiratory workers.

Language: Английский

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