Effects of Early Psychological Trauma on Limbic System Structure and Function

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry, Journal Year: 2024, Volume and Issue: 16(4), P. 691 - 706

Published: April 14, 2024

This paper aims to review the subtypes of childhood trauma and its effects on brain structures function, especially hippocampus amygdala within limbic system, in context clinical psychology. For this purpose, original articles published between 1996 2024 were systematically searched major databases such as PubMed, PsycArticles, Web Science, Google Scholar using keywords early trauma, psychological hippocampus, amygdala, neuroimaging. The initially screened based their titles, those meeting search criteria, including study population, investigated regions, types traumas, further assessed for relevance. Ultimately, 136 selected discussed review. Trauma experiences life can have a significantly negative influence person's health by causing neurodevelopmental impairments, system. While it is understood that influences how individuals think, behave, feel, results neuroimaging studies reveal variations different subtypes. These changes merit deeper investigation future research fully understand reasons behind diverse findings existing literature.

Language: Английский

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PV and SST neurons in the anterior cingulate cortex regulate social disorders in adulthood induced by sensory abnormalities in childhood

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Abstract Objective Childhood sensory abnormalities experience has a crucial influence on the structure and function of adult brain. The underlying mechanism neurological induced by childhood is still unclear. Our study was to investigate whether GABAergic neurons in anterior cingulate cortex (ACC) regulate social disorders caused experience. Methods We used two mouse models, complete Freund's adjuvant (CFA) injection mice bilateral whisker trimming (BWT) childhood. applied immunofluorescence, chemogenetic optogenetic parvalbumin (PV) somatostatin (SST) ACC regulating Results Inflammatory pain leads preference disorders, while BWT novelty mice. an increase number PV SST neurons, respectively, ACC. Inhibiting improved that experienced inflammatory during Conclusions reveals may play critical role

Language: Английский

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Association between adverse childhood experiences and obesity, and sex differences: A systematic review and meta-analysis

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 180, P. 56 - 67

Published: Oct. 8, 2024

Language: Английский

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Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 5, 2024

Childhood maltreatment (CM) is linked to long-term adverse health outcomes, including accelerated biological aging and cognitive decline. This study investigates the relationship between CM various biomarkers: telomere length, facial aging, intrinsic epigenetic age acceleration (IEAA), GrimAge, HannumAge, PhenoAge, frailty index, performance.

Language: Английский

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