α -Lipoic acid alleviates Parkinson’s disease by suppressing S100A9-mediated pyroptosis

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114539 - 114539

Published: April 14, 2025

Language: Английский

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Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 11, 2024

Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that ferroptosis plays role in OA development. However, most research has concentrated on regulation involving typical iron ions, potentially neglecting significance elevated copper ions both serum fluid patients with OA. This review aims fill this gap systematically examining interplay between metabolism, oxidative stress, ferroptosis, copper-associated death It will provide comprehensive overview ions' regulating their dual approach seeks offer new insights for further research, prevention, treatment

Language: Английский

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Exploring the Efficacy of Alpha-Lipoic Acid in Comorbid Osteoarthritis and Type 2 Diabetes Mellitus

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3349 - 3349

Published: Oct. 2, 2024

Background/Objectives. The comorbidity of osteoarthritis and type 2 diabetes mellitus poses a complex clinical challenge, complicating patient management due to overlapping pathophysiological mechanisms. This research aims analyze the exacerbation symptoms biochemical markers in patients with OA T2DM compared those alone. Methods. We employed various assessment methods evaluate inflammation, oxidative stress, glycemic control both cohorts. study includes administration alpha-lipoic acid (ALA) comorbid T2DM, monitoring its effects on joint function, inflammatory markers, stress levels, control. Results. findings indicate that significantly worsens patients. Those conditions exhibited elevated indicators inflammation OA-only Additionally, correlations among metabolic, psychological, factors were identified. Body mass index emerged as potential predictor for deterioration evaluated parameters. analysis revealed ALA led statistically significant improvements WOMAC pain scores, Lequesne Algofunctional Index, AIMS-P group. Conclusions. Further into ALA’s progression comorbidities is essential developing personalized treatment approaches.

Language: Английский

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α-Lipoic acid: a potential regulator of copper metabolism in Alzheimer’s disease

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 3, 2024

Alzheimer’s disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeostasis, particularly involving copper, have gained significant attention. In AD pathology, an imbalance evident: there excess of extracellular copper alongside a deficiency intracellular brain tissue. Our previous work demonstrated that α-lipoic acid (LA) can effectively shift from the space environment neuronal cell model. However, precise mechanism action role LA metabolism remained elusive. this study, we compared cellular effects with those different synthetic copper-binding ligands: diethyldithiocarbamate (DETC), clioquinol (CQ), D-penicillamine (D-PA) elesclomol (ES). Using differentiated SH-SY5Y culture model, found that, unlike other compounds, natural ligand not toxic presence even at high doses. gradually increased levels over 24 h. contrast, DETC, CQ, ES acted fast ionophores, potentially explaining their higher toxicity LA. D-PA did facilitate uptake into cells. We slow increase inside cells enhanced copper. Furthermore, ability modulate equilibrium extra- was evident when added isotope 65 Cu. The ratio isotopes changed rapidly, reflecting impact on distribution without affecting transport network. results provide compelling evidence holds promise non-toxic agent capable normalizing disease.

Language: Английский

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A Near-infrared Fluorescent Probe for Sensing Cuprous ions

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136982 - 136982

Published: Nov. 1, 2024

Language: Английский

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Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated with Alzheimer′s Disease

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Abstract Oxidative stress and blood-brain barrier (BBB) disruption due to brain endothelial dysfunction contribute Alzheimer’s Disease (AD), which is characterized by beta-amyloid (Aβ) accumulation in senile plaques. Copper (Cu) implicated AD pathology its levels are tightly controlled several Cu transport proteins. However, their expression role AD, particularly relation function remains unclear. In this study, we examined the of proteins brains mouse models as well involvement Aβ42-induced dysfunction. We found that uptake transporter CTR1 was upregulated, while exporter ATP7A and/or ATP7B were downregulated hippocampus models, Aβ42-treated human microvascular cells (hBMECs). 5xFAD model, (assessed ICP-MS) elevated hippocampus. Moreover, reactive oxygen species (ROS) production, ROS-dependent loss hBMEC (measured transendothelial electrical resistance), tyrosine phosphorylation VE-cadherin all inhibited either a membrane permeable chelator or knocking down expression. These findings suggest dysregulated may lead intracellular brain, Aβ42 promotes VE-Cadherin CTR1-Cu-dependent manner. Our study uncovers critical oxidative stress-related BBB integrity AD. Highlights Upregulation importer downregulation increases reduces ECs. triggers increased production ECs through CTR1- Cu-dependent induces CTR1-Cu-ROS-pendent

Language: Английский

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Identification of diagnostic markers and molecular clusters of cuproptosis-related genes in alcohol-related liver disease based on machine learning and experimental validation

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37612 - e37612

Published: Sept. 1, 2024

Language: Английский

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Targeted and non-targeted proteomics to identify the urinary protein biomarkers for Wilson disease

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120090 - 120090

Published: Dec. 1, 2024

Language: Английский

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Hippo-YAP signaling alleviates copper-induced mitochondrial dysfunction and oxidative damage via the ATOX1-PPA2 pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 290, P. 138908 - 138908

Published: Dec. 18, 2024

Language: Английский

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