Cited by Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping

Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons DOI

Frank Raven, Alexis Vega-Medina,

Kailynn Schmidt

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Study objectives Brief sleep loss alters cognition and synaptic structures of principal neurons in hippocampus neocortex. However, while vivo recording bioinformatic data suggest that inhibitory interneurons are more strongly affected by loss, it is unclear how deprivation affect interneurons’ synapses. Disruption the SST+ interneuron population seems to be a critical early sign neuropathology Alzheimer’s dementia, schizophrenia, bipolar disorder - risk developing all three increased habitual loss. We aimed test various brain regions brief disruption. Methods used Brainbow 3.0 label dorsal hippocampus, prefrontal cortex, visual cortex male SST-CRE transgenic mice, then compared labeled after 6-h period ad lib sleep, or gentle handling (SD) starting at lights on. Results Dendritic spine density among both neocortex was altered subregion-specific manner, with overall thin CA1, dramatic increases volume surface area CA3, small but significant changes (primarily decreases) size PFC V1. Conclusions Our connectivity significantly region-specific manner few hours This suggests cell type-specific mechanism which disrupts excitatory-inhibitory balance networks. Significance Statement Changes function somatostatin-expressing (SST+) have been implicated etiology psychiatric neurological disorders behavior affected. Here, we measure effects very experimental on neocortex, for sleep-dependent memory processing. find only six restructures dendritic spines, causing widespread size. These potential dramatically alter across these networks, leading cognitive disruptions commonly associated

Language: Английский

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Towards an Understanding of the Dentate Gyrus Hilus DOI

Helen E. Scharfman

Hippocampus, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 25, 2024

For many years, the hilus of dentate gyrus (DG) was a mystery because anatomical data suggested bewildering array cells without clear organization. Moreover, some information led to more questions than answers. example, it had been identified that one major cell types in hilus, mossy cell, innervates granule (GCs). However, also targeted local GABAergic neurons. Furthermore, not yet if were glutamatergic or GABAergic. This debates about role cells. hilar neurons, including cells, likely have very important functions they provided strong input GCs. Hilar neurons attracted attention epilepsy pathological studies showed often lost, but GCs remained. Vulnerability occurred after traumatic brain injury and ischemia. These observations fueled an interest understand protect them, continues this day. article provides historical personal perspective into ways I sought contribute resolving moving field forward. Despite several technical challenges outcomes worth effort with surprising findings along way. Given growing advent multiple techniques selectively manipulate there is great opportunity for future research.

Language: Английский

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Persistent Interruption in Parvalbumin Positive Inhibitory Interneurons: Biophysical and Mathematical Mechanisms DOI

Carol Upchurch, Christopher J. Knowlton, Simon Chamberland

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

Persistent activity in principal cells is a putative mechanism for maintaining memory traces during working memory. We recently demonstrated persistent interruption of firing fast-spiking parvalbumin-expressing interneurons (PV-INs), phenomenon which could serve as substrate through disinhibition lasting hundreds milliseconds. Here, we find that hippocampal CA1 PV-INs exhibit type 2 excitability, like striatal and neocortical PV-INs. Modelling mathematical analysis showed the slowly inactivating potassium current K

Language: Английский

Citations

Persistent Interruption in Parvalbumin-Positive Inhibitory Interneurons: Biophysical and Mathematical Mechanisms DOI

Carol M. Upchurch,

Christopher J. Knowlton, Simon Chamberland

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(7), P. ENEURO.0190 - 24.2024

Published: June 17, 2024

Persistent activity in excitatory pyramidal cells (PYRs) is a putative mechanism for maintaining memory traces during working memory. We have recently demonstrated persistent interruption of firing fast-spiking parvalbumin-expressing interneurons (PV-INs), phenomenon that could serve as substrate PYRs through disinhibition lasting hundreds milliseconds. Here, we find hippocampal CA1 PV-INs exhibit type 2 excitability, like striatal and neocortical PV-INs. Modeling mathematical analysis showed the slowly inactivating potassium current K V 1 contributes to enables multiple regimes observed experimentally PV-INs, provides robust firing. Using fast/slow separation times scales approach with inactivation variable bifurcation parameter shows initial inhibitory stimulus stops repetitive by moving membrane potential trajectory onto coexisting stable fixed point corresponding nonspiking quiescent state. As decays, follows branch points until it crosses subcritical Hopf (HB) then spirals out into In model describing entorhinal cortical without 1, be achieved taking advantage bistability inherent excitability based on HB, but was not noise. therefore broadly applicable different brain regions only made noise presence slow variable, inactivation.

Language: Английский

Citations

Understanding OLM interneurons: Characterization, circuitry, and significance in memory and navigation DOI

Beatriz Fernández-Arroyo,

Sandra Jurado, Juan Lerma

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Understanding the intricate mechanisms underlying memory formation and retention relies on unraveling how hippocampus, a structure fundamental for acquisition, is organized. Within complex hippocampal network, interneurons play crucial role in orchestrating processes. Among these interneurons, Oriens-Lacunosum Moleculare (OLM) cells emerge as key regulators, governing flow of information to CA1 pyramidal cells. In this review, we explore OLM detail, describing their effects processing, particularly spatial contextual tasks. Our aim provide detailed understanding contribute dynamic landscape retrieval.

Language: Английский

Citations

Ventral hippocampal interneurons govern extinction and relapse of contextual associations DOI

Anthony F. Lacagnina, Tri Dong,

Rasika R. Iyer

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114880 - 114880

Published: Oct. 18, 2024

Language: Английский

Citations

Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping DOI

Matt Udakis,

Matthew D.B. Claydon,

Heng Wei Zhu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Summary OLM interneurons selectively target inhibition to the distal dendrites of CA1 pyramidal cells in hippocampus but role this unique morphology controlling place cell physiology remains a mystery. Here we show that activity prevents associative synaptic plasticity at Schaffer collateral synapses on by inhibiting dendritic Ca 2+ signalling initiated entorhinal inputs. Furthermore, find is reduced novel environments suggesting reducing and thereby enhancing excitatory important for formation new representations. Supporting this, increasing enhances stability reduces remapping newly formed whilst familiar led only transient silencing cells. Our results therefore demonstrate critical dendrite targeting regulating neuronal

Language: Английский

Citations