Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 23, 2024
Language: Английский
Citations
20
Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)
Published: Feb. 7, 2025
Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances remarkable correlation between dysbiosis extraintestinal cancers, underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their metabolites, can undermine integrity barrier through inflammatory or metabolic pathways, leading increased permeability translocation pathogens. dissemination pathogens circulation may contribute establishment an immune-suppressive environment that promotes carcinogenesis organs either directly indirectly. oncogenic cascade always engages disruption hormonal regulation responses, induction genomic instability mutations, dysregulation adult stem cell proliferation. This review aims comprehensively summarize existing evidence points potential malignant transformation such as liver, breast, lung, pancreas. Additionally, we delve into limitations inherent current methodologies, particularly challenges associated differentiating low loads gut-derived microbiome within tumors from sample contamination symbiotic microorganisms. Although still controversial, understanding contribution translocated metabolites pathological continuum chronic inflammation could offer novel foundation for development targeted therapeutics.
Language: Английский
Citations
2
Gut Microbes, Journal Year: 2024, Volume and Issue: 17(1)
Published: Dec. 24, 2024
The initiation and progression of colorectal cancer (CRC) are intimately associated with genetic, environmental biological factors. Desulfovibrio vulgaris (DSV), a sulfate-reducing bacterium, has been found excessive growth in CRC patients, suggesting potential role carcinogenesis. However, the precise mechanisms underlying this association remain incompletely understood. We have was abundant high-fat diet-induced Apcmin/+ mice, DSV, member Desulfovibrio, triggered colonocyte proliferation germ-free mice. Furthermore, level DSV progressively rose from healthy individuals to patients. Flagella important accessory structures bacteria, which can help them colonize enhance their invasive ability. that D. flagellin (DVF) drove proliferation, migration, invasion cells fostered xenografts. DVF enriched epithelial-mesenchymal transition (EMT)-associated genes characterized facilitation on EMT. Mechanistically, induced EMT through functional transmembrane receptor called leucine-rich repeat containing 19 (LRRC19). interacted LRRC19 modulate ubiquitination tumor necrosis factor receptor-associated (TRAF)6, rather than TRAF2. This interaction pivotal molecule TAK1, further enhancing its autophosphorylation ultimately contributing Collectively, interacts activate TRAF6/TAK1 signaling pathway, thereby promoting CRC. These data shed new light gut microbiota establish clinical therapeutic target.
Language: Английский
Citations
5
Trends in cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
5
Breast Cancer Research, Journal Year: 2025, Volume and Issue: 27(1)
Published: Jan. 6, 2025
Neoadjuvant chemotherapy (NACT) is the standard-of-care treatment for patients with locally advanced breast cancer (LABC), providing crucial benefits in tumor downstaging. Clinical parameters, such as molecular subtypes, influence therapeutic impact of NACT. Moreover, severe adverse events delay process and reduce effectiveness therapy. Although metabolic changes during are determinant factors responses toxicities, related clinical research remains limited. One hundred paired blood samples were collected from 50 LABC before after a complete NACT cycle. Untargeted metabolomics was used by liquid chromatography-mass spectrometry (LC–MS) to investigate relationship between dynamically changing metabolites serum toxicities Firstly, we observed significant alterations metabolite levels pre- post-NACT, predominant enrichment sphingolipid amino acid metabolism pathways. Second, pre-treatment successfully predicted response hematotoxicities In particular, subtype variations favorable linked acyl carnitine levels. Finally, discovered that effects could be attributed essential metabolism. This study elucidated dynamic treatment, possibility developing responsive signatures personalized treatment.
Language: Английский
Citations
0
International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 29, 2025
Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney cancer, and osteoporosis. However, studies have uncovered novel aspect of HSD, suggesting that may inhibit growth specific pathological conditions by modulating the activity immune cells infiltrate tumors enhancing effectiveness PD-1 immunotherapy. This review focused duel molecular mechanisms cancer development, which are based microenvironment, gut microbiota, involvement sodium transporter channels. The objective this is to explore whether could be potential future oncological therapeutic strategy under situation.
Language: Английский
Citations
0
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Feb. 4, 2025
Abstract Amino acids are pivotal regulators of immune cell metabolism, signaling pathways, and gene expression. In myeloid cells, these processes underlie their functional plasticity, enabling shifts between pro-inflammatory, anti-inflammatory, pro-tumor, anti-tumor activities. Within the tumor microenvironment, amino acid metabolism plays a crucial role in mediating immunosuppressive functions contributing to progression. This review delves into mechanisms by which specific acids—glutamine, serine, arginine, tryptophan—regulate function polarization. Furthermore, we explore therapeutic potential targeting enhance immunity, offering insights novel strategies for cancer treatment.
Language: Английский
Citations
0
Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(4)
Published: Feb. 1, 2025
ABSTRACT Background Reducing the incidence of breast cancer and improving its prognosis have become significant challenges for global public health sector. We aimed to investigate role circulating triglycerides in occurrence survival patients with cancer, while focusing on possible differential effects by molecular subtypes cancer. Methods used a Mendelian randomization approach analyze publicly accessible genome‐wide association study data, including triglyceride levels, risk, prognosis. performed two‐sample causality inference analysis using inverse‐variance weighted method. both randomization–Egger regression median methods model verification. Heterogeneity was evaluated Cochran's Q test, sensitivity analyses were leave‐one‐out method, intercept Randomization Pleiotropy RESidual Sum Outlier test. Results The results revealed negative causal relationship between levels overall risk (odds ratio [OR] = 0.94, confidence interval [CI] 0.89–0.99, p 0.011), luminal A (OR 0.93, CI 0.87–0.99, 0.014), human epidermal growth factor receptor 2 (HER2)‐enriched 0.84, 0.73–0.96, 0.010). However, no statistically correlations observed B, B HER2‐negative, triple‐negative subtypes. Furthermore, showed positive estrogen receptor‐negative 1.33, 1.00–1.76, 0.047). impact or receptor‐positive, HER2‐positive, HER2‐negative Conclusions potentially complex provides new perspective heterogeneity thereby promoting development precise medical strategies. Moreover, our findings contribute an increased understanding among clinicians alike.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141933 - 141933
Published: March 1, 2025
Language: Английский
Citations
0