Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity DOI Creative Commons
Ting Xu,

Chunhong Zhu,

Xinqi Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский

The central renin–angiotensin system: A genetic pathway, functional decoding, and selective target engagement characterization in humans DOI
Ting Xu, Zhiyi Chen, Xinqi Zhou

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(8)

Published: Feb. 13, 2024

Accumulating evidence suggests that the brain renin angiotensin system (RAS) plays a pivotal role in regulation of cognition and behavior as well neuropathology neurological mental disorders. The II type 1 receptor (AT1R) mediates most functional neuropathology-relevant actions associated with central RAS. However, an overarching comprehension to guide translation utilize therapeutic potential RAS humans is currently lacking. We conducted comprehensive characterization using innovative combination transcriptomic gene expression mapping, image-based behavioral decoding, pre-registered randomized controlled discovery–replication pharmacological resting-state magnetic resonance imaging (fMRI) trials (N = 132) selective AT1R antagonist. exhibited particular dense subcortical network encompassing thalamus, striatum, amygdalo-hippocampal formation. Behavioral decoding map showed association memory, stress, reward, motivational processes. Transient blockade further decreased neural activity systems characterized by high expression, while increasing connectivity cortico-basal ganglia-thalamo-cortical circuitry. Effects on level were specifically signatures dopaminergic, opioid, acetylcholine, corticotropin-releasing hormone signaling systems. robustness results was supported independent fMRI trial. These findings present biologically informed pathways their relevance humans.

Language: Английский

Citations

6
Distinct neural computations scale the violation of expected reward and emotion in social transgressions DOI Creative Commons
Ting Xu, Lei Zhang, Feng Zhou

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 21, 2025

Traditional decision-making models conceptualize humans as adaptive learners utilizing the differences between expected and actual rewards (prediction errors, PEs) to maximize outcomes, but rarely consider influence of violations emotional expectations (emotional how it differs from reward PEs. Here, we conducted a fMRI experiment (n = 43) using modified Ultimatum Game examine PEs affect punishment decisions in terms rejecting unfair offers. Our results revealed that relative exerted stronger prediction decisions. On neural level, left dorsomedial prefrontal cortex (dmPFC) was strongly activated during receipt whereas emotions engaged bilateral anterior insula. Reward were also encoded differently brain-wide multivariate patterns, with more sensitive signature observed within fronto-insular circuits for PE. We further identified network encompassing cingulate cortex, insula, dmPFC inferior frontal gyrus In addition, pattern expression under PE predicted These findings underscore interact shape complex social interactions, while underlying neurofunctional computations are distinguishable. evaluations guide regarding norm-violating proposer, these processes being mediated by distinct computation.

Language: Английский

Citations

0
Angiotensin receptor blockade modulates resting state functional connectivity in the memory network rather than fear network – implications for posttraumatic stress disorder DOI
Lorika Shkreli, Caroline Nettekoven,

Sirius Boessenkool

et al.

Psychiatry Research, Journal Year: 2025, Volume and Issue: unknown, P. 116458 - 116458

Published: March 1, 2025

Language: Английский

Citations

0
Distinct neural computations scale the violation of expected reward and emotion in social transgressions DOI Creative Commons
Ting Xu, Lei Zhang, Feng Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

ABSTRACT Traditional decision-making models conceptualize humans as optimal learners aiming to maximize outcomes by leveraging reward prediction errors (PE). While violated emotional expectations (emotional PEs) have recently been formalized, the underlying neurofunctional basis and whether it differs from PEs remain unclear. Using a modified fMRI Ultimatum Game on n=43 participants we modelled in response unfair offers subsequent punishment decisions. Computational modelling revealed distinct contributions of decisions, with PE exerting stronger impact. This process was neurofunctionally dissociable such that (1) engaged dorsomedial prefrontal cortex while experience recruited anterior insula, (2) multivariate decoding accurately separated PEs. Predictive neural expressions but not fronto-insular systems predicted behavioral Overall, these findings suggest neurocomputational processes underlie which uniquely impact social

Language: Английский

Citations

2
Contribution of Visceral Systems to the Development of Substance Use Disorders: Translational Aspects of Interaction between Central and Peripheral Mechanisms DOI Creative Commons
Д. И. Перегуд, N. V. Gulyaeva

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(11), P. 1868 - 1888

Published: Nov. 1, 2024

Language: Английский

Citations

2
Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity DOI Creative Commons
Ting Xu,

Chunhong Zhu,

Xinqi Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский

Citations

0