Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond DOI Creative Commons
Lara Camillo, Elisa Zavattaro, Paola Savoia

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 254 - 254

Published: Feb. 1, 2025

Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD⁺) and NADPH. NAD⁺ integral numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, senescence, aging. NAM supplementation has demonstrated efficacy in restoring energy, repairing damage, inhibiting inflammation by suppressing pro-inflammatory cytokines release. Due its natural presence variety foods excellent safety profile—even at high doses up 3 g/day—NAM extensively used chemoprevention non-melanoma skin cancers treatment dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, acne vulgaris. Recently, anti-aging properties have elevated NAM’s prominence skincare formulations. Beyond repair energy replenishment, significantly impacts oxidative stress reduction, cell cycle apoptosis modulation. Despite these multifaceted benefits, comprehensive molecular mechanisms underlying actions remain not fully elucidated. This review consolidates recent research shed light on mechanisms, emphasizing critical role health therapeutic potential. By enhancing our understanding, this work underscores importance continued exploration into applications, aiming inform future clinical practices innovations.

Language: Английский

1,25(OH)₂D₃ Regulates Androgen Synthesis via Transcriptional Control of Steroidogenic Enzymes and LHR in the Scented Glands of Muskrats (Ondatra zibethicus) DOI

Qingjing Gao,

Xuedong Shi, Yuning Liu

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Melanocyte and Nerve Fiber Cross‐Talk, Facilitated Also by Semaphorin‐4A, Enhances UV‐B‐Induced Melanogenesis DOI

Onur Egriboz,

Markus Fehrholz, Moe Tsutsumi

et al.

Pigment Cell & Melanoma Research, Journal Year: 2025, Volume and Issue: 38(1)

Published: Jan. 1, 2025

ABSTRACT Epidermal melanocytes form synaptic‐like contacts with cutaneous nerve fibers, but the functional outcome of these connections remains elusive. In this pilot study we used our fully humanized re‐innervated skin organ culture model to investigate melanocyte‐nerve fiber interactions in UV‐B‐induced melanogenesis. UV‐B‐irradiation significantly enhanced melanin content and tyrosinase activity compared non‐innervated controls, indicating that neuronal presence is essential for exacerbating pigmentation upon UV‐B irradiation long‐term culture. Comparative transcriptomic analysis between laser‐capture‐microdissected from freshly embedded human published microarray data on vitro primary identified Semaphorin‐4A (SEMA4A) as possible mediator fibers interactions. SEMA4A protein levels Gp100 + ‐epidermal were higher skin, reduced by treatment. Analysis showed expression 24 h after while secretion into medium was increased. Beta‐tubulin axon growth sensory neurons stimulated conditioned media (CM) irradiated melanocytes. When neuronal‐conditioned transferred fresh melanocytes, increased, only if had been treated CM These findings highlight importance melanocyte‐neuron melanogenesis suggest secreted proteins (e.g., SEMA4A) can function a novel target treat hypo‐ hyperpigmentation disorders.

Language: Английский

Citations

0
Activation of Local 11β‐Hydroxysteroid Dehydrogenase Type 1 by Diosmetin Enhances Endogenous Glucocorticoid Levels to Alleviate Skin Inflammation: Insights Into a Novel Therapeutic Strategy for Atopic Dermatitis DOI Open Access
Hyun Ju Kang,

Hyun Jee Hwang,

Eunjung Kim

et al.

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(2)

Published: Jan. 30, 2025

ABSTRACT Glucocorticoids (GCs) are synthesised de novo by peripheral tissues and the adrenal cortex of hypothalamic–pituitary–adrenal axis. Skin expresses an enzyme called 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1), which reduces cortisone to active hormone cortisol activates GC receptors. 11β‐HSD1 plays a significant role in alleviating atopic inflammation through elevation concentrations skin. This study aimed investigate diosmetin as activator (11β‐HSD1). In human keratinocytes, was found upregulate protein expression levels, well transcriptional mRNA. However, this upregulation mRNA abrogated keratinocytes transfected with small interfering RNA (siRNA). dermatitis (AD) murine model, topical administration significantly attenuated basal transepidermal water loss (TEWL) Eczema Area Severity Index (EASI), while enhancing stratum corneum (SC) hydration. Diosmetin also increased corticosterone levels SC upregulated both serum epidermis. Furthermore, treatment led marked reduction immunoglobulin E (IgE) tumour necrosis factor‐α (TNF‐α) suppressed thymic stromal lymphopoietin (TSLP), interleukin‐1β (IL‐1β), IL‐4, IL‐13 Collectively, these findings suggest that promotes endogenous activation glucocorticoids via local activation, underscoring its potential novel therapeutic agent for management inflammatory skin disorders, such AD.

Language: Английский

Citations

0
Research progress on anti-aging effects and mechanisms of the new ginsenoside Compound K DOI Creative Commons

Zhiqin Fang,

Jingyin Zhang,

Jianwen Huang

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 100072 - 100072

Published: Jan. 31, 2025

Language: Английский

Citations

0
Nicotinamide: A Multifaceted Molecule in Skin Health and Beyond DOI Creative Commons
Lara Camillo, Elisa Zavattaro, Paola Savoia

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 254 - 254

Published: Feb. 1, 2025

Nicotinamide (NAM), the amide form of vitamin B3, is a precursor to essential cofactors nicotinamide adenine dinucleotide (NAD⁺) and NADPH. NAD⁺ integral numerous cellular processes, including metabolism regulation, ATP production, mitochondrial respiration, reactive oxygen species (ROS) management, DNA repair, senescence, aging. NAM supplementation has demonstrated efficacy in restoring energy, repairing damage, inhibiting inflammation by suppressing pro-inflammatory cytokines release. Due its natural presence variety foods excellent safety profile—even at high doses up 3 g/day—NAM extensively used chemoprevention non-melanoma skin cancers treatment dermatological conditions such as blistering diseases, atopic dermatitis, rosacea, acne vulgaris. Recently, anti-aging properties have elevated NAM’s prominence skincare formulations. Beyond repair energy replenishment, significantly impacts oxidative stress reduction, cell cycle apoptosis modulation. Despite these multifaceted benefits, comprehensive molecular mechanisms underlying actions remain not fully elucidated. This review consolidates recent research shed light on mechanisms, emphasizing critical role health therapeutic potential. By enhancing our understanding, this work underscores importance continued exploration into applications, aiming inform future clinical practices innovations.

Language: Английский

Citations

0