MAIT cells: Conserved watchers on the wall

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 222(1)

Published: Oct. 24, 2024

MAIT cells are innate-like T residing in barrier tissues such as the lung, skin, and intestine. Both semi-invariant cell receptor of restricting element MR1 deeply conserved across mammals, indicating non-redundant functions linked to antigenic specificity. species concomitantly express cytotoxicity tissue-repair genes, suggesting versatile functions. Accordingly, contribute antibacterial responses well repair damaged tissues. recognize riboflavin biosynthetic pathway-derived metabolites, which rapidly cross epithelial barriers be presented by antigen-presenting cells. Changes gut ecology during intestinal inflammation drive expansion strong ligand producers. Thus, may enable real-time surveillance microbiota dysbiosis intact epithelia provide rapid context-dependent responses. Here, we discuss recent findings regarding origin regulation ligands role We speculate on potential reasons for conservation evolution.

Language: Английский

The microbiota shapes the life trajectory of mucosal-associated invariant T cells

Trends in Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский