Harnessing BDNF Signaling to Promote Resilience in Aging DOI Open Access
Jamshid Faraji, Gerlinde A. S. Metz

Published: July 29, 2024

As a key member of the neurotrophin family in central nervous system, brain-derived neurotrophic factor (BDNF) plays critical role maintenance and plasticity system. Its innate neuroprotective advantage can also be shared with brain when normal aging-dependent processes challenge neural circuits. The intricate relationship between BDNF resilience during aging process signifies molecular mechanisms that underlie protection function, such as cognition, movement psychological well-being. is crucial for neuronal growth survival, it promote against age-related functional decline frailty, even if fails to entirely prevent ageing-related decline. In present review, we discuss function from perspective how may aging. We emphasize briefly principal, well-known cellular hallmarks restrict disabling dynamics enhance overall Insight into pathways through which reduces dysfunctions and/or improves resilience, provide foundation developing targeted interventions mental well-being an population.

Language: Английский

Role of Post-Transcriptional Regulation in Learning and Memory in Mammals DOI Open Access
Carlo Maria Di Liegro, Gabriella Schiera,

Giuseppe Schirò

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(3), P. 337 - 337

Published: March 5, 2024

After many decades, during which most molecular studies on the regulation of gene expression focused transcriptional events, it was realized that post-transcriptional control equally important in order to determine where and when specific proteins were be synthesized. Translational is importance brain, all steps mRNA maturation, transport different regions cells actual expression, response signals, constitute basis for neuronal plasticity and, as a consequence, structural stabilization/modification synapses; notably, these latter events are fundamental highest brain functions, such learning memory, characterized by long-term potentiation (LTP) synapses. Here, we will discuss bases considering both role RNA-binding (RBPs) effects non-coding RNAs involved controlling splicing, editing, stability translation mRNAs. Importantly, has also been found dysregulation metabolism/localization pathological conditions, arising either development or adult nervous system.

Language: Английский

Citations

2
Harnessing BDNF Signaling to Promote Resilience in Aging DOI Creative Commons
Jamshid Faraji, Gerlinde A. S. Metz

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

As a key member of the neurotrophin family in central nervous system, brain-derived neurotrophic factor (BDNF) plays critical role maintenance and plasticity system. Its innate neuroprotective advantage can also be shared with brain when normal aging-dependent processes challenge neural circuits. The intricate relationship between BDNF resilience during aging process signifies molecular mechanisms that underlie protection function, such as cognition, movement psychological well-being. is crucial for neuronal growth survival, it promote against age-related functional decline frailty, even if fails to entirely prevent aging-related decline. In present review, we discuss function from perspective how may aging. We emphasize briefly principal, well-known cellular hallmarks restrict disabling dynamics enhance overall Insight into pathways through which reduces dysfunctions and/or improves resilience, provides foundation developing targeted interventions mental well-being an population.

Language: Английский

Citations

2
Memristive Artificial Synapses Based on Brownmillerite for Endurable Weight Modulation DOI
Yoon Jung Lee,

Eun-Seok Choi,

Ji Hyun Baek

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Exploring a computing paradigm that blends memory and computation functions is essential for artificial synapses. While memristors synapses are widely studied due to their energy-efficient structures, random filament conduction in general makes them less preferred endurability long-term synaptic modulation. Herein, the topotactic phase transition (TPT) brownmillerite-phased (110)-SrCoO

Language: Английский

Citations

0
Adaptive synaptic mechanisms: The role of metaplasticity in synaptic tagging and capture DOI

Saranya Jayapragas,

Lei Yin, Sreedharan Sajikumar

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Data-driven synapse classification reveals a logic of glutamate receptor composition DOI Creative Commons
Kristina D. Micheva, Anish K. Simhal,

Jenna Schardt

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Summary The rich diversity of synapses facilitates the capacity neural circuits to transmit, process and store information. Here, we used multiplex super-resolution proteometric imaging through array tomography define features single in adult mouse neocortex. We find that glutamatergic cluster into subclasses parallel distinct biochemical functional categories receptor subunits: GluA1/4, GluA2/3 GluN1/GluN2B. Two these align with physiological expectations based on synaptic plasticity: large AMPAR-rich may represent potentiated synapses, whereas small NMDAR-rich suggest “silent” synapses. NMDA content correlates spine neck diameter, thus potential for coupling parent dendrite. Conjugate tomography’s rigorous registration immunofluorescence electron microscopy provides validation future studies other systems. No barriers prevent generalization this approach species, laying a foundation human disorders therapeutics. Highlights enables validates single-synapse proteometry Glutamate identifies places synapse ultrastructural context Subclasses established molecular plasticity Graphical Abstract

Language: Английский

Citations

0
Harnessing BDNF Signaling to Promote Resilience in Aging DOI Open Access
Jamshid Faraji, Gerlinde A. S. Metz

Published: July 29, 2024

As a key member of the neurotrophin family in central nervous system, brain-derived neurotrophic factor (BDNF) plays critical role maintenance and plasticity system. Its innate neuroprotective advantage can also be shared with brain when normal aging-dependent processes challenge neural circuits. The intricate relationship between BDNF resilience during aging process signifies molecular mechanisms that underlie protection function, such as cognition, movement psychological well-being. is crucial for neuronal growth survival, it promote against age-related functional decline frailty, even if fails to entirely prevent ageing-related decline. In present review, we discuss function from perspective how may aging. We emphasize briefly principal, well-known cellular hallmarks restrict disabling dynamics enhance overall Insight into pathways through which reduces dysfunctions and/or improves resilience, provide foundation developing targeted interventions mental well-being an population.

Language: Английский

Citations

0