Biophysical mechanisms of default mode network function and dysfunction DOI Creative Commons
Trang-Anh E. Nghiem, Vinod Menon

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The default mode network (DMN) plays a fundamental role in internal cognitive function as well dysfunction across numerous brain disorders. While human and rodent neuroimaging has revealed DMN suppression by salient external stimuli, the cellular mechanisms orchestrating this process remain unknown. Using whole-brain computational modeling informed neuronal biophysics retrograde tracer-derived directional mouse connectomics, we demonstrate that stimulation of insula, involved salience processing, suppresses activity while within-DMN cingulate enhances it. Manipulating excitatory-inhibitory balance how localized disruptions propagate to cause distinct patterns dysfunction, with both reversals paradoxical enhancements normal patterns. Brain-wide response analysis uncovered functionally segregated frontal hierarchical organization from regions. These findings provide unified framework linking large-scale dynamics region-specific might lead observed

Language: Английский

Basal Forebrain Projections to the Retrosplenial and Cingulate Cortex in Rats DOI Creative Commons
Hideki Kondo, László Záborszky

The Journal of Comparative Neurology, Journal Year: 2025, Volume and Issue: 533(2)

Published: Feb. 1, 2025

The basal forebrain (BF) plays a crucial role in modulating cortical activation through its widespread projections across the mantle. Previous anatomical studies have demonstrated that each region receives specific projection from BF. In this study, we examined BF cholinergic and non-cholinergic to retrosplenial cortex (RSC) anterior cingulate (ACC) using two retrograde tracers, Fast Blue (FB) Fluoro-Gold (FG), combination with choline acetyltransferase (ChAT) immunostaining rats. RSC ACC receive mainly medial part of horizontal limb diagonal band (HDB) vertical (VDB). main difference RSC, ACC, prelimbic (PL) is PL rostral half globus pallidus (GP), whereas stronger VDB septum (MS). As injection site shifts caudal strong GP weak MS/VDB neurons are reversed. Cholinergic make up similar proportion total both (37%) (33%) injections. Double tracer injections revealed small number double-labeled HDB. These findings indicate spatially overlapping differential BF, varying between subregions different rostrocaudal regions.

Language: Английский

Citations

0
Biophysical mechanisms of default mode network function and dysfunction DOI Creative Commons
Trang-Anh E. Nghiem, Vinod Menon

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract The default mode network (DMN) plays a fundamental role in internal cognitive function as well dysfunction across numerous brain disorders. While human and rodent neuroimaging has revealed DMN suppression by salient external stimuli, the cellular mechanisms orchestrating this process remain unknown. Using whole-brain computational modeling informed neuronal biophysics retrograde tracer-derived directional mouse connectomics, we demonstrate that stimulation of insula, involved salience processing, suppresses activity while within-DMN cingulate enhances it. Manipulating excitatory-inhibitory balance how localized disruptions propagate to cause distinct patterns dysfunction, with both reversals paradoxical enhancements normal patterns. Brain-wide response analysis uncovered functionally segregated frontal hierarchical organization from regions. These findings provide unified framework linking large-scale dynamics region-specific might lead observed

Language: Английский

Citations

0