Global Use of Bovine Heparin: Challenges and Opportunities

Proteoglycan Research, Journal Year: 2025, Volume and Issue: 3(2)

Published: April 1, 2025

ABSTRACT Heparin is a vital anticoagulant widely employed in medicine for endovascular procedures, hemodialysis, and the treatment prevention of thrombosis. Traditionally derived from porcine intestinal mucosa, this dependency poses significant risks, including geographic concentration reliance on single animal species. Bovine‐derived heparin offers viable scalable alternative, though structural functional differences have historically limited its broad clinical adoption. This review underscores between bovine heparins while highlighting advances production high‐anticoagulant (HABH), form with properties comparable to porcine‐derived heparin. HABH also serves as raw material bovine‐derived low molecular weight (LMWH) production, addressing global supply chain vulnerabilities providing sustainable solution demands. Additionally, process yields low‐anticoagulant (LABH), cost‐effective byproduct potential applications non‐anticoagulant heparin, demonstrated antitumoral antimetastatic properties. Despite challenges such regulatory hurdles, scalability, economic constraints, presents promising strategy diversify chain, reduce sources, provide religiously acceptable enhance access critical therapies worldwide.

Language: Английский

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Non-Thermal Stabilization Strategies for Rice Bran: Mechanistic Insights, Technological Advances, and Implications for Industrial Applications

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1448 - 1448

Published: April 22, 2025

Rice bran, a major byproduct of rice processing, is rich in unsaturated fatty acids, high-quality proteins, and bioactive compounds such as γ-oryzanol ferulic acid. However, its poor storage stability susceptibility to hydrolytic oxidative rancidity critically limit industrial exploitation. Recent advances non-thermal stabilization technologies—valued for their energy efficiency, scalability, nutrient preservation—offer promising solutions. This review systematically elucidates the enzymatic microbial mechanisms driving bran rancidity, emphasizing lipase lipoxygenase activity, evaluates efficacy emerging strategies. Key findings highlight superiority methods: cold plasma reduces activity by 70% within 5 min via reactive oxygen species-induced structural disruption; ultra-high pressure preserves 95% selectively breaking hydrogen bonds enzymes; high-energy electron beam irradiation suppresses markers 45–78%; with immobilized papain achieves 78% inactivation while retaining <5% loss. Compared thermal approaches, technologies enhance retention, extending shelf-life 2–3 weeks. By addressing challenges synergy, parameter optimization, this provides actionable insights deploying green, energy-efficient strategies valorize into functional foods nutraceuticals, aligning global demands sustainable ingredient innovation.

Language: Английский

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Role, binding properties, and potential therapeutical use of Glycosaminoglycans and mimetics in SARS-CoV-2 infection. In memory of Dr. Robert Linhardt (1953–2025)

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123703 - 123703

Published: May 1, 2025

Language: Английский

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Overview of the current procedures in synthesis of heparin saccharides

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 339, P. 122220 - 122220

Published: May 3, 2024

Natural heparin, a glycosaminoglycan consisting of repeating hexuronic acid and glucosamine linked by 1 → 4 glycosidic bonds, is the most widely used anticoagulant. To subvert dependence on animal sourced alternative methods to produce heparin saccharides, i.e., either heterogenous sugar chains similar natural or structurally defined oligosaccharides, are becoming hot subjects. Although success chemical synthesis pentasaccharide, fondaparinux, encourages proceed through approach generating homogenous product, synthesizing larger oligos still cumbersome beyond reach so far. Alternatively, chemoenzymatic pathway exhibited exquisite stereoselectivity glycosylation regioselectivity modification, with advantage skip tedious protection steps unavoidable in synthesis. However, scale drug production needed today not sight. In comparison, procedure de novo biosynthesis an organism could be ultimate goal. The main purpose this review summarize current available/developing strategies techniques, which expected provide comprehensive picture for saccharides replenish eventually replace derived products. approaches, methodologies discussed according procedures: building block preparation, chain elongation, backbone modification.

Language: Английский

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Bioengineered heparin: Advances in production technology

Biotechnology Advances, Journal Year: 2024, Volume and Issue: unknown, P. 108456 - 108456

Published: Sept. 1, 2024

Language: Английский

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Multifaceted Heparin: Diverse Applications beyond Anticoagulant Therapy

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1362 - 1362

Published: Oct. 12, 2024

Heparin, a naturally occurring polysaccharide, has fascinated researchers and clinicians for nearly century due to its versatile biological properties been used various therapeutic purposes. Discovered in the early 20th century, heparin key anticoagulant ever since, use is now implemented as life-saving pharmacological intervention management of thrombotic disorders beyond. In addition known properties, found exhibit anti-inflammatory, antiviral, anti-tumorigenic activities, which may lead widespread future an essential drug against infectious diseases such COVID-19 medical treatments. Furthermore, recent advancements nanotechnology, including nano-drug delivery systems nanomaterials, have significantly enhanced intrinsic biofunctionalities heparin. These breakthroughs paved way innovative applications medicine therapy, expanding potential research. Therefore, this review aims provide creation profile heparin, space utilities complications, characteristics bioengineering nanotechnology. It also discusses challenges opportunities realizing full improve patient outcomes elevate interventions.

Language: Английский

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Heparin and heparan sulfate—The essence of sequence

Proteoglycan Research, Journal Year: 2024, Volume and Issue: 2(4)

Published: Oct. 1, 2024

Abstract Heparin, discovered as an anticoagulant more than 100 years ago, is composed of the same structural units heparan sulfate, and their biosynthesis in Golgi compartment carried out by families enzymes. However, while heparin restricted to mast cells, sulfate widely distributed found at cell surface most, if not all, cells body also basement membranes extracellular matrix surrounding cells. Compared highly sulfated heparin, has a complex variable structure that yet appears regulated tissue‐specific fashion. Interactions proteins with may be controlled through subtle changes binding saccharide domains, resulting modulated functional response. Unpredicted effects enzyme overexpression on point key roles for interacting networks—the "GAGosome"—in regulation biosynthesis.

Language: Английский

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Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Dec. 6, 2024

Microphysiological systems (MPS) and Organs-on-Chips (OoCs) hold significant potential for replicating complex human biological processes

Language: Английский

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