Gut,
Journal Year:
2024,
Volume and Issue:
73(11), P. 1893 - 1908
Published: Sept. 25, 2024
The
understanding
that
changes
in
microbiome
composition
can
influence
chronic
human
diseases
and
the
efficiency
of
therapies
has
driven
efforts
to
develop
microbiota-centred
such
as
first
next
generation
probiotics,
prebiotics
postbiotics,
microbiota
editing
faecal
transplantation.
Central
research
is
how
disease
impacts
vice
versa,
yet
there
a
problematic
issue
with
term
'dysbiosis',
which
broadly
links
microbial
imbalances
various
illnesses
without
precision
or
definition.
Another
significant
discussions
defining
'healthy
individuals'
ascertain
what
characterises
healthy
microbiome.
This
involves
questioning
who
represents
healthiest
segment
our
population-whether
it
those
free
from
illnesses,
athletes
at
peak
performance,
individuals
living
healthily
through
regular
exercise
good
nutrition
even
elderly
adults
centenarians
have
been
tested
by
time
achieved
remarkable
longevity.This
review
advocates
for
delineating
'what
defines
microbiome?'
considering
broader
range
factors
related
health
environmental
influences
on
microbiota.
A
undoubtedly
linked
gut
health.
Nevertheless,
very
difficult
pinpoint
universally
accepted
definition
'gut
health'
due
complexities
measuring
functionality
besides
composition.
We
must
take
into
account
individual
variabilities,
diet,
lifestyle,
host
factors.
Moreover,
challenge
distinguishing
causation
correlation
between
overall
presented.The
also
highlights
resource-heavy
nature
comprehensive
assessments,
hinders
their
practicality
broad
application.
Finally,
we
call
continued
nuanced
approach
better
understand
intricate
evolving
concept
health,
emphasising
need
more
precise
inclusive
definitions
methodologies
studying
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(21), P. 6578 - 6578
Published: Nov. 1, 2024
Colorectal
cancer
(CRC)
constitutes
a
significant
global
health
challenge,
with
recent
studies
underscoring
the
pivotal
role
of
gut
microbiome
in
its
pathogenesis
and
progression.
Fecal
microbiota
transplantation
(FMT)
has
emerged
as
compelling
therapeutic
approach,
offering
potential
to
modulate
microbial
composition
optimize
treatment
outcomes.
Research
suggests
that
specific
bacterial
strains
are
closely
linked
CRC,
influencing
both
clinical
management
interventions.
Moreover,
microbiome's
impact
on
immunotherapy
responsiveness
heralds
new
avenues
for
personalized
medicine.
Despite
promise
FMT,
safety
concerns,
particularly
immunocompromised
individuals,
remain
critical
issue.
Clinical
outcomes
vary
widely,
influenced
by
genetic
predispositions
methodologies
employed.
Additionally,
rigorous
donor
selection
screening
protocols
paramount
minimize
risks
maximize
efficacy.
The
current
body
literature
advocates
establishment
standardized
further
trials
substantiate
FMT's
CRC
management.
As
our
understanding
deepens,
FMT
is
poised
become
cornerstone
treatment,
imperative
continued
research
validation.
Cell Host & Microbe,
Journal Year:
2024,
Volume and Issue:
32(6), P. 820 - 836
Published: June 1, 2024
Microbial
communities
that
colonize
the
human
gastrointestinal
(GI)
tract
defend
against
pathogens
through
a
mechanism
known
as
colonization
resistance
(CR).
Advances
in
technologies
such
next-generation
sequencing,
gnotobiotic
mouse
models,
and
bacterial
cultivation
have
enhanced
our
understanding
of
underlying
mechanisms
intricate
microbial
interactions
involved
CR.
Rather
than
being
attributed
to
specific
clades,
CR
is
now
understood
arise
from
dynamic
interplay
between
microbes
host
shaped
by
metabolic,
immune,
environmental
factors.
This
evolving
perspective
underscores
significance
contextual
factors,
encompassing
microbiome
composition
conditions,
determining
review
highlights
recent
research
has
shifted
its
focus
toward
elucidating
how
these
factors
interact
either
promote
or
impede
enteric
infections.
It
further
discusses
future
directions
unravel
complex
relationship
host,
microbiota,
determinants
safeguarding
GI
infections
health.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 29, 2025
The
intricate
relationship
between
dietary
habits
and
cognitive
function
is
gaining
increasing
attention,
with
a
focus
on
the
gut-brain
axis
as
modifiable
target
for
intervention.
This
review
synthesizes
evidence
impact
of
patterns,
particularly
Mediterranean
diet,
plant-based
diets,
low-carbohydrate
health.
These
rich
in
antioxidants,
anti-inflammatory
compounds,
neuroprotective
nutrients,
are
suggested
to
slow
decline
reduce
risk
neurodegenerative
disorders
through
mechanisms
such
reduced
inflammation
oxidative
stress,
enhanced
neurogenesis.
diet
has
been
associated
improved
performance
delay
elderly
populations.
However,
challenges
intervention
implementation,
including
adherence
individual
variability,
remain.
Future
research
must
adopt
multidisciplinary
approach,
incorporating
long-term,
large-scale,
multicenter
randomized
controlled
trials
assess
enduring
impacts
various
patterns
function,
considering
socioeconomic
cultural
factors.
underscores
potential
interventions
prevent
mitigate
impairment,
ultimately
aiming
improve
quality
life.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(6)
Published: Feb. 7, 2025
Mucosa-associated
invariant
T
(MAIT)
cells
are
a
large
population
of
unconventional
widely
distributed
in
the
human
gastrointestinal
tract.
Their
homing
to
gut
is
central
maintaining
mucosal
homeostasis
and
immunity.
This
review
discusses
potential
mechanisms
that
guide
MAIT
intestinal
mucosa
during
inflammation,
emphasizing
roles
chemokines,
chemokine
receptors,
tissue
adhesion
molecules.
The
influence
microbiota
on
cell
different
regions
also
discussed.
Last,
we
introduce
how
organoid
technology
offers
potentially
valuable
approach
advance
our
understanding
by
providing
more
physiologically
relevant
model
mimics
tissue.
These
models
may
enable
detailed
investigation
gut-specific
cells.
By
regulation
gut,
avenues
for
therapeutic
interventions
targeting
inflammatory
conditions
such
as
bowel
diseases
(IBD)
emerge.
Gastrointestinal Disorders,
Journal Year:
2024,
Volume and Issue:
6(4), P. 801 - 815
Published: Sept. 27, 2024
The
gut
microbiome
plays
a
crucial
role
in
human
health
by
influencing
various
physiological
functions
through
complex
interactions
with
the
endocrine
system.
These
involve
production
of
metabolites,
signaling
molecules,
and
direct
communication
cells,
which
modulate
hormone
secretion
activity.
As
result,
can
exert
neuroendocrine
effects
contribute
to
metabolic
regulation,
adiposity,
appetite
control.
Additionally,
influences
reproductive
altering
levels
sex
hormones
such
as
estrogen
testosterone,
potentially
contributing
conditions
like
polycystic
ovary
syndrome
(PCOS)
hypogonadism.
Given
these
roles,
targeting
offers
researchers
clinicians
novel
opportunities
improve
overall
well-being.
Probiotics,
