Lipid Membrane Domains Control Actin Network Viscoelasticity DOI Creative Commons
Daniel P. Arnold, Sho C. Takatori

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

The mammalian cell membrane is embedded with biomolecular condensates of protein and lipid clusters, which interact an underlying viscoelastic cytoskeleton network to organize the surface mechanically extracellular environment. However, mechanical thermodynamic interplay between liquid–liquid phase separation 2-dimensional (2D) remains poorly understood. Here, we engineer materials composed 2D within a thin actin network. generates localized anisotropic stresses that deform into triangular morphologies sharp edges corners, shapes unseen in many 3D composite gels. Kinetic coarsening phase-separating accelerates relaxation network, leading effectively softer material over intermediate time scales. We dynamically manipulate composition control elastic-to-viscous crossover Such membranes may enable development coatings, catalytic surfaces, membranes, other interfaces tunable spatial organization plasticity mechanisms.

Language: Английский

A New Measure for an Acceptable Level of Homogeneity in Meta-Informatics DOI Creative Commons
Ramalingam Shanmugam, Karan P. Singh

Mathematics, Journal Year: 2025, Volume and Issue: 13(9), P. 1364 - 1364

Published: April 22, 2025

This paper addresses the challenges in assessing heterogeneity meta-analytic studies. The specifics include mental health research work. Three key statistical scores meta-analytics—Higgins’ I2, Birge’s H2, and newly developed S2 score—are discussed illustrated. critiques subjectivity of these introduces elasticity to enhance accuracy objectivity heterogeneity. integration into meta-informatic score measures how changes as new studies are added, improving interpretation results. Also, authors compute compare context research, offering a novel approach visualizing quantifying demonstrate improves assessment recommends use score, integrated with elasticity, for more reliable objective conclusions well other meta-analyses. rectified S2, overcomes issues I2 when chi-squared distribution fails due small sample sizes or negative values.

Language: Английский

Citations

0
Bread and hummus: trait connectance and correlation pleiades in grain crops DOI Creative Commons
Víctor O. Sadras

Journal of Experimental Botany, Journal Year: 2024, Volume and Issue: 75(22), P. 6903 - 6908

Published: Sept. 7, 2024

Language: Английский

Citations

1
Lipid Membrane Domains Control Actin Network Viscoelasticity DOI Creative Commons
Daniel P. Arnold, Sho C. Takatori

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

The mammalian cell membrane is embedded with biomolecular condensates of protein and lipid clusters, which interact an underlying viscoelastic cytoskeleton network to organize the surface mechanically extracellular environment. However, mechanical thermodynamic interplay between liquid–liquid phase separation 2-dimensional (2D) remains poorly understood. Here, we engineer materials composed 2D within a thin actin network. generates localized anisotropic stresses that deform into triangular morphologies sharp edges corners, shapes unseen in many 3D composite gels. Kinetic coarsening phase-separating accelerates relaxation network, leading effectively softer material over intermediate time scales. We dynamically manipulate composition control elastic-to-viscous crossover Such membranes may enable development coatings, catalytic surfaces, membranes, other interfaces tunable spatial organization plasticity mechanisms.

Language: Английский

Citations

0