bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Neurons of the primate ventral premotor cortex (VPC) respond to tactile or acoustic stimuli. But how VPC neurons process and integrate information from these two sensory modalities during perception remains unknown. To investigate this, we recorded activity in trained monkeys performing a bimodal detection task (BDT). In BDT, subjects reported presence absence an stimulus. Initial single-cell analyses revealed diverse range responses BDT: purely tactile, acoustic, others that exhibited sustained decision maintenance delay—between stimulus offset motor report. further explore VPC’s role applied dimensionality reduction techniques uncover low-dimensional latent dynamics neuronal population conducted parallel on recurrent neural network (RNN) model same task. Neural trajectories associated with diverged strongly those related responses. Conversely, stimulus-absent trials remained at rest. During delay, demonstrated pronounced rotational dynamic toward subspace orthogonal response space, supporting memory stable equilibria. This suggests can sustain distinct states corresponding three potential outcomes. Using modeling, propose universal dynamical mechanism underlying transition mnemonic processing, consistent our experimental computational observations. These findings show contains capable coding its competing maintain decisions throughout delay period, regardless modality.

Language: Английский