Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection DOI Creative Commons
Tina T. Liu, Michael C. Granovetter, Anne Margarette S. Maallo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The topographic organization of category-selective responses in human ventral occipitotemporal cortex (VOTC) and its relationship to regions subserving language functions is remarkably uniform across individuals. This arrangement thought result from the clustering neurons responding similar inputs, constrained by intrinsic architecture tuned experience. We examined malleability this individuals with unilateral resection VOTC during childhood for management drug-resistant epilepsy. In cross-sectional longitudinal functional imaging studies, we compared topography neural representations 17 a resection, ‘control patient’ outside VOTC, typically developing matched controls. demonstrated both adherence deviation standard uncovered fine-grained competitive dynamics between word- face-selectivity over time single, preserved VOTC. findings elucidate nature extent cortical plasticity highlight potential remodeling extrastriate function. Teaser After pediatric deviations constraints visual reflect plasticity.

Language: Английский

Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection DOI Creative Commons
Michael C. Granovetter, Anne Margarette S. Maallo, Shouyu Ling

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Abstract In the typically developing (TD) brain, neural representations for visual stimulus categories (e.g., faces, objects, and words) emerge in bilateral occipitotemporal cortex (OTC), albeit with weighted asymmetry; parallel, recognition behavior continues to be refined. A fundamental question is whether two hemispheres are necessary or redundant emergence of distributed across both hemispheres. The rare population patients undergoing unilateral OTC resection childhood offers a unique opportunity evaluate computations individuation suffice only single OTC. Here, using functional magnetic resonance imaging, we mapped category selectivity (CS) individual exemplars repetition suppression (RS) non-resected hemisphere pediatric ( n = 9) control outside 12), as well TD controls 21). There were no univariate group differences magnitude CS RS any multivariate (per representational similarity analysis) activation words groups. Notwithstanding their comparable profiles, accuracy on face object recognition, but not word was statistically inferior that controls. signature patients’ preserved other groups highlights resilience system following damage contralateral homologue. Critically, however, does normal behavior, and, thereby, implicates necessity

Language: Английский

Citations

1
Functional Resilience of the Neural Visual Recognition System Post-Pediatric Occipitotemporal Resection DOI Creative Commons
Michael C. Granovetter, Anne Margarette S. Maallo, Shouyu Ling

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111440 - 111440

Published: Nov. 22, 2024

Language: Английский

Citations

0
Cross-sectional and longitudinal changes in category-selectivity in visual cortex following pediatric cortical resection DOI Creative Commons
Tina T. Liu, Michael C. Granovetter, Anne Margarette S. Maallo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract The topographic organization of category-selective responses in human ventral occipitotemporal cortex (VOTC) and its relationship to regions subserving language functions is remarkably uniform across individuals. This arrangement thought result from the clustering neurons responding similar inputs, constrained by intrinsic architecture tuned experience. We examined malleability this individuals with unilateral resection VOTC during childhood for management drug-resistant epilepsy. In cross-sectional longitudinal functional imaging studies, we compared topography neural representations 17 a resection, ‘control patient’ outside VOTC, typically developing matched controls. demonstrated both adherence deviation standard uncovered fine-grained competitive dynamics between word- face-selectivity over time single, preserved VOTC. findings elucidate nature extent cortical plasticity highlight potential remodeling extrastriate function. Teaser After pediatric deviations constraints visual reflect plasticity.

Language: Английский

Citations

0