Controlling the Dynamic Behavior of Microposts in Solution via Diffusion–Convection

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Solutal buoyancy forces in solution arise from density gradients, which occur when the reactants and products of a chemical reaction occupy different volumes fluid. These drive fluids to spontaneously perform self-directed mechanical work such as shaping organizing flexible objects fluid-filled microchambers. Here, we use theory simulation show that reactions are not necessary generate useful solutal forces; it is sufficient just add aqueous solutions have mass-to-volume ratio than water spontaneous action. To demonstrate this behavior, model arrays tethered, nonreactive posts chamber. Relatively dense chemicals released chamber's side walls diffuse into buoyancy-driven flows, trigger undergo collective dynamics. The posts' dynamics can be controllably programmed by staging sequence release walls. With chemically active within array, turning on off influx leads propagating waves exhibit biomimetic coordinated motion. introduction cascade dynamically shifts direction wave propagation. Our findings how diffusion-convection diffusion-reaction-convection processes used regulate nonequilibrium spatiotemporal behavior fluidic systems. This level control vital for creating portable microfluidic devices operate without external power sources thus function remote or resource-poor locations.

Language: Английский

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Imaging gastric cancer metastasis progression in an organotypic, three-dimensional functional model of the human peritoneum

Pleura and Peritoneum, Journal Year: 2025, Volume and Issue: 10(1), P. 11 - 17

Published: March 1, 2025

Abstract Objectives Despite the introduction of multimodal treatment regimens, prognosis gastric cancer peritoneal metastasis (GCPM) remains poor. To establish efficient therapies, a deeper understanding pathophysiological mechanisms in development GCPM is necessary and this requires adequate functional models. Therefore, we established three-dimensional model to study tumor adhesion, invasion growth. Methods A co-culture mesothelial cells with fibroblasts collagen I was cultivated further seed human cell lines on surface. Different imaging techniques (optical microscopy, immunohistochemistry, scanning (SEM) transmission (TEM) electron microscopy) served as tools proof sustainability model. Results We demonstrated feasibility creating robust showed that reproducible under various conditions (6-, 12-, 24-wells) pre-analytical processing possible. The feasible allowed comparison morphological changes normal peritoneum. Conclusions organotypic which can be used generate knowledge pathophysiology might serve platform for testing different chemotherapy schemes order personalized patients GCPM.

Language: Английский

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Wireless Peristaltic Pump for Transporting Viscous Fluids and Solid Cargos in Confined Spaces

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: June 2, 2024

Abstract The transport of fluids and solids is a vital process inside the human body, facilitated by wave‐like motion in lumen called peristalsis. However, peristalsis may be compromised due to tumor growth, resulting difficulties motility. dysmotility can result blockages pose numerous challenges, including aspiration lungs reproductive issues female oviduct. Restoring medical devices, such as stents, prevent device blockage promote effective transport. Here, wirelessly actuated soft robotic undulating pump designed efficiently both viscous fluidic solid cargos proposed. kinematics single sheet coordination between pairs are systematically generate undulation peristalsis, enabling pumping liquids solids. integration demonstrated onto an esophageal stent. same motion‐based mechanism adapted for usage other organs, oviduct, thereby offering potential applications treating various diseases. proposed holds promise facilitating diverse implantable devices aimed at diseases characterized impaired dysmotility.

Language: Английский

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Fluid mediated communication among flexible micro-posts in chemically reactive solutions

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Modeling shows that enzymatic reactions at microposts in solution trigger chemo-mechanical interactions spontaneously convey distinct signals over extensive distances fluid-filled chambers.

Language: Английский

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