The Oviposition Inhibitory Neuron is a potential hub of multi-circuit integration in the Drosophila brain DOI Open Access

Rhessa Weber Langstaff,

Pranjal Srivastava, Alexander B. Kunin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Abstract Understanding how neural circuits integrate sensory and state information to support context-dependent behavior is a central issue in neuroscience. In Drosophila, oviposition complex process which the fly integrates context choose an optimal location lay her eggs. The circuit that controls sequence known, but multiple modalities internal states not. We investigated circuitry underlying high-level processing related using Hemibrain connectome. identified Oviposition Inhibitory Neuron (oviIN) as key hub analyzed its inputs uncover potential parallel pathways may be responsible for computations decision-making. applied graph-theoretic analyses on sub-connectome of oviIN identify modules neurons constitute novel circuits. Our findings indicate form from unstructured neuropils Superior Protocerebrum where have been known occur.

Language: Английский

Parallel and converging multisensory cascades in the Drosophila connectome DOI Creative Commons
Richard F. Betzel, Maria Grazia Puxeddu, Caio Seguin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Connectomes are network maps of synaptic connectivity. A key functional role any connectome is to constrain inter-neuronal signaling and sculpt the flow activity across nervous system. therefore play a central in rapid tranmission information about an organism’s environment from sensory neurons higher-order for action planning ultimately effectors. Here, we use parsimonious model spread investigate connectome’s shaping putative cascades. Our allows us simulate pathways sensors rest brain, mapping similarity these between different modalities identifying convergence zones–neurons that activated simultaneously by modalities. Further, considered two multisensory integration scenarios – cooperative case where interacted “speed up” (reduce) neurons’ activation times competitive “winner take all” case, streams vied same neural territory. Finally, data-driven algorithm partition into classes based on their behavior during cascade simulations. work helps underscore “simple” models enriching data, while offering classification joint connectional/dynamical properties.

Language: Английский

Citations

1
The Oviposition Inhibitory Neuron is a potential hub of multi-circuit integration in the Drosophila brain DOI Open Access

Rhessa Weber Langstaff,

Pranjal Srivastava, Alexander B. Kunin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Abstract Understanding how neural circuits integrate sensory and state information to support context-dependent behavior is a central issue in neuroscience. In Drosophila, oviposition complex process which the fly integrates context choose an optimal location lay her eggs. The circuit that controls sequence known, but multiple modalities internal states not. We investigated circuitry underlying high-level processing related using Hemibrain connectome. identified Oviposition Inhibitory Neuron (oviIN) as key hub analyzed its inputs uncover potential parallel pathways may be responsible for computations decision-making. applied graph-theoretic analyses on sub-connectome of oviIN identify modules neurons constitute novel circuits. Our findings indicate form from unstructured neuropils Superior Protocerebrum where have been known occur.

Language: Английский

Citations

0