Lab life, seasons and chromosome fusions restrict non-cell-autonomously proliferation and neurogenesis, but not oligodendrogenesis, in mice and voles DOI Creative Commons

Athanasia Rapti,

Theodosia Androutsopoulou,

Evangelia Andreopoulou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Abstract Environmental and behavioral factors have been shown, in experimental settings, to affect neurogenesis the mouse brain. We found that density of proliferating neural stem/ progenitor cells (NSPCs) neuroblasts was significantly lower Subependymal Zone stem cell niche lab mice when compared with pine voles captured wild, seasonal variation observed only voles. Moreover, levels proliferation were decrease proportion numbers chromosomes (from typical 2n = 40 down 26) caused by Robertsonian fusions. In contrast, oligodendroglial progenitors microglial unaffected wildlife, seasons chromosomal When NSPCs grown cultures no differences detected, suggesting environmental genetic effects are mediated non-cell-autonomous mechanisms. These “real-world” data provide a platform for identification systemic loci control postnatal brain neurogenesis.

Language: Английский

Immune control of brain physiology DOI
Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
The choroid plexus: a command center for brain–body communication during inflammation DOI
Huixin Xu, Christine Hehnly, Maria K. Lehtinen

et al.

Current Opinion in Immunology, Journal Year: 2025, Volume and Issue: 93, P. 102540 - 102540

Published: Feb. 27, 2025

Language: Английский

Citations

0
Research priorities for non-invasive therapies to improve hydrocephalus outcomes DOI Creative Commons
Alexandra Hochstetler, Christine Hehnly,

W. R. Dawes

et al.

Fluids and Barriers of the CNS, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 3, 2025

The Hydrocephalus Association organized two workshops with the support of Rudi Schulte Research Institute and Cincinnati Children's Hospital Medical Center entitled "Developing Non-Invasive Therapies: Molecular Cellular Targets", held September 27–29, 2023, in Dallas, TX, Advancing Towards Clinical Trials", April 12–13, 2024, Cincinnati, OH. goal these was to explore frontiers ongoing research for non-invasive therapies treatment hydrocephalus across all etiologies improve patient outcomes at stages diagnosis management. During consensus-building discussions throughout workshops, basic, translational, clinical scientists aimed identify next steps develop novel treatments hydrocephalus. This detailed report discusses priorities that emerged from inspire researchers guide studies towards better people living

Language: Английский

Citations

0
IFN-γ signaling links ventriculomegaly to choroid plexus and ependyma dysfunction following maternal immune activation DOI Creative Commons

Yuqin Sun,

Xinxin Huang, Wei Guo

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 15, 2025

Maternal immune activation (MIA) is a principal environmental risk factor contributing to autism spectrum disorder (ASD) and can be causally linked ASD symptoms. In our study, we found that MIA triggered by poly (I: C) injection caused ventriculomegaly in offspring due the dysfunction of choroid plexus (Chp) ependyma. We subsequently identified sustained enhancement interferon-γ (IFN-γ) signaling brain serum offspring. Further study revealed increased IFN-γ could disrupt barrier function Chp epithelial cells activating macrophages, suppress differentiation primary ependymal via signal transducer activator transcription 1/3 signaling. The effects on were mitigated administration IFNGR-blocking antibody pregnant dams, while systemic maternal was sufficient mimic effect MIA. Overall, findings critical compromising fetal development MIA-induced provide mechanistic framework for association between inflammation abnormal ventricles

Language: Английский

Citations

0
Choroid plexus: Insights from distinct epithelial cellular components DOI Creative Commons

Valentina Scarpetta,

Kim Hoa Ho,

Marleen Trapp

et al.

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 93, P. 103028 - 103028

Published: April 22, 2025

The choroid plexus (ChP) serves as a vital interface between blood and cerebrospinal fluid (CSF), playing pivotal role in central nervous system (CNS) development communication with the body. This review mainly summarizes how ChP epithelial cells respond to physiological pathological stimuli, emphasizing of distinct organelles key molecular signaling pathways. Additionally, we discuss roles cilia, an evolutionary conserved organelle whose function is still under investigation. Understanding these processes essential for elucidating modulates intrinsic extrinsic which are crucial maintaining CNS body homeostasis.

Language: Английский

Citations

0
Breakthroughs in choroid plexus and CSF biology from the first European Choroid plexus Scientific Forum (ECSF) DOI Creative Commons
Laura Pellegrini,

Violeta Silva-Vargas,

Annarita Patrizi

et al.

Fluids and Barriers of the CNS, Journal Year: 2024, Volume and Issue: 21(1)

Published: May 21, 2024

Abstract The European Choroid plexus Scientific Forum (ECSF), held in Heidelberg, Germany between the 7th and 9th of November 2023, involved 21 speakers from eight countries. ECSF focused on discussing cutting-edge fundamental medical research related to development functions choroid its implications for health, aging, disease, including tumors. In addition new findings this expanding field, innovative approaches, animal models 3D vitro were showcased encourage further investigation into cerebrospinal fluid roles.

Language: Английский

Citations

0
Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder DOI Creative Commons
B. Bravi, Marco Paolini,

Melania Maccario

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Aim One‐third of patients with major depressive disorder (MDD) do not achieve full remission and have high relapse rates even after treatment, leading to increased medical costs reduced quality life health status. The possible specificity treatment‐resistant depression (TRD) neurobiology is still under investigation, risk factors such as higher inflammatory markers being identified. Given recent findings on the role choroid plexus (ChP) in neuroinflammation hippocampus treatment response, aim present study was evaluate inflammatory‐ trophic‐related differences these regions along ventricular volumes among treatment‐sensitive (TSD), TRD, healthy controls (HCs). Methods ChP, hippocampal, were assessed 197 MDD 58 age‐ sex‐matched HCs. Volumes estimated using FreeSurfer 7.2. Treatment resistance status defined failure respond at least two separate antidepressant treatments. Region interest then compared groups. Results We found ChP TRD TSD Our results also showed lower hippocampal lateral both without Conclusions These corroborate link between neuroinflammation, volume could be considered a putative marker central immune activity. lack significant all region HCs may highlight features possibly providing new insights into specific neurobiological underpinnings this condition.

Language: Английский

Citations

0
Lab life, seasons and chromosome fusions restrict non-cell-autonomously proliferation and neurogenesis, but not oligodendrogenesis, in mice and voles DOI Creative Commons

Athanasia Rapti,

Theodosia Androutsopoulou,

Evangelia Andreopoulou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Abstract Environmental and behavioral factors have been shown, in experimental settings, to affect neurogenesis the mouse brain. We found that density of proliferating neural stem/ progenitor cells (NSPCs) neuroblasts was significantly lower Subependymal Zone stem cell niche lab mice when compared with pine voles captured wild, seasonal variation observed only voles. Moreover, levels proliferation were decrease proportion numbers chromosomes (from typical 2n = 40 down 26) caused by Robertsonian fusions. In contrast, oligodendroglial progenitors microglial unaffected wildlife, seasons chromosomal When NSPCs grown cultures no differences detected, suggesting environmental genetic effects are mediated non-cell-autonomous mechanisms. These “real-world” data provide a platform for identification systemic loci control postnatal brain neurogenesis.

Language: Английский

Citations

0