bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
Despite
significant
progress
in
brain
circuit
mapping
over
recent
decades,
a
major
challenge
remains:
no
method
currently
allows
for
the
noninvasive
modulation
of
genetically
and
spatially
defined
neural
populations
while
simultaneously
monitoring
their
global
effects
throughout
body.
Here,
we
present
sonogenetic-fPET,
technique
that
integrates
sonogenetics
with
[
18
F]-2-fluoro-2-deoxy-D-glucose
functional
positron
emission
tomography
(FDG-fPET)
to
overcome
this
challenge.
Sonogenetics
enables
noninvasive,
targeted
neurons
engineered
express
ultrasound-sensitive
ion
channel
TRPV1,
FDG-fPET
captures
glucose
metabolic
changes
triggered
by
stimulation
across
We
demonstrate
effectiveness
targeting
dorsal
striatum,
showcasing
its
capability
map
network
responses
specific
neuronal
activation.
Incorporating
an
acoustic
hologram
further
flexible
different
regions
within
single
mouse
concurrently
resulting
activity.
In
summary,
sonogenetic-fPET
offers
tool
dissecting
body
populations.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Abstract
The
diagnosis
and
treatment
of
cancer
face
significant
challenges.
Thus,
precise
controllable
methods
for
effective
tumor
management
are
required.
Sonogenetics
which
combines
ultrasound
technology
with
genetic
engineering
provides
a
promising
solution.
This
approach
utilizes
the
non‐invasive
nature
deep
tissue
penetration
capabilities
to
enable
diagnostics
targeted
therapies
cancer.
review
explores
roles
sonogenetics‐mediated
in
theranostics.
fundamental
properties
mechanisms
underlying
sonogenetics
first
introduced.
Then,
this
work
summarizes
representative
applications
therapy,
including
cell‐based
therapies,
bacteria‐based
eradication
cells.
Additionally,
diagnosis,
focusing
on
engineered
gas
vesicles
(GVs)
situ
generation
GVs
diagnostic
purposes
presented.
Finally,
challenges
clinical
translation
potential
well
discussed.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
Despite
significant
progress
in
brain
circuit
mapping
over
recent
decades,
a
major
challenge
remains:
no
method
currently
allows
for
the
noninvasive
modulation
of
genetically
and
spatially
defined
neural
populations
while
simultaneously
monitoring
their
global
effects
throughout
body.
Here,
we
present
sonogenetic-fPET,
technique
that
integrates
sonogenetics
with
[
18
F]-2-fluoro-2-deoxy-D-glucose
functional
positron
emission
tomography
(FDG-fPET)
to
overcome
this
challenge.
Sonogenetics
enables
noninvasive,
targeted
neurons
engineered
express
ultrasound-sensitive
ion
channel
TRPV1,
FDG-fPET
captures
glucose
metabolic
changes
triggered
by
stimulation
across
We
demonstrate
effectiveness
targeting
dorsal
striatum,
showcasing
its
capability
map
network
responses
specific
neuronal
activation.
Incorporating
an
acoustic
hologram
further
flexible
different
regions
within
single
mouse
concurrently
resulting
activity.
In
summary,
sonogenetic-fPET
offers
tool
dissecting
body
populations.
