Interleukin-34-dependent perivascular macrophages promote vascular function in the brain DOI Creative Commons
Hannah Van Hove, Chaim Glück, Wiebke Mildenberger

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

The development of most macrophages depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interleukin-34 (IL-34). While IL-34 is required for homeostasis microglia, parenchymal in central nervous system (CNS), it unclear whether brain border-associated (BAMs) also depend this cytokine. Here, we demonstrated that embryonic murine BAMs choroid plexus, leptomeninges, perivascular spaces CSF-1, while was critical their maintenance adulthood. In brain, Il34 expressed by mural cells fibroblasts, its transgenic deletion these interrupted BAM maintenance. deficiency coincided with transcriptional changes vascular cells, leading to increased flow velocity vasomotion pial penetrating arterioles. Similarly, Mrc1CreCsf1rfl/fl mice lacking CD206+ exhibited hemodynamics arterial networks. These findings reveal a crosstalk between CNS regulating cerebrovascular function.

Language: Английский

Collateral blood vessels in stroke and ischemic disease: Formation, physiology, rarefaction, remodeling DOI Creative Commons
James E. Faber

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Collateral blood vessels are unique, naturally occurring endogenous bypass that provide alternative pathways for oxygen delivery in obstructive arterial conditions and diseases. Surprisingly however, the capacity of collateral circulation to protection varies greatly among individuals, resulting a significant fraction having poor their tissues. We recently reviewed evidence presence naturally-occurring polymorphisms genes determine number diameter collaterals form during development (ie, genetic background), is major contributor this variation. The purpose review summarize current understanding other determinants flow, drawing on both animal human studies. These include level smooth muscle tone collaterals, hemodynamic forces, how (collaterogenesis), de novo formation additional new adulthood, loss with aging cardiovascular risk factor (rarefaction), remodeling (structural lumen enlargement). also emerging not only ischemic but may serve physiological function healthy individuals. Primary focus studies conducted brain, however relevant findings tissues reviewed, as questions future investigation.

Language: Английский

Citations

0
Interleukin-34-dependent perivascular macrophages promote vascular function in the brain DOI Creative Commons
Hannah Van Hove, Chaim Glück, Wiebke Mildenberger

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

The development of most macrophages depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interleukin-34 (IL-34). While IL-34 is required for homeostasis microglia, parenchymal in central nervous system (CNS), it unclear whether brain border-associated (BAMs) also depend this cytokine. Here, we demonstrated that embryonic murine BAMs choroid plexus, leptomeninges, perivascular spaces CSF-1, while was critical their maintenance adulthood. In brain, Il34 expressed by mural cells fibroblasts, its transgenic deletion these interrupted BAM maintenance. deficiency coincided with transcriptional changes vascular cells, leading to increased flow velocity vasomotion pial penetrating arterioles. Similarly, Mrc1CreCsf1rfl/fl mice lacking CD206+ exhibited hemodynamics arterial networks. These findings reveal a crosstalk between CNS regulating cerebrovascular function.

Language: Английский

Citations

0