Reply to Rollin et al.: Clarifying the multifactorial origins of racial disparities in uterine serous carcinoma DOI Creative Commons
Julie Kim, Michael A. Simon, Gini F. Fleming

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)

Published: Oct. 14, 2024

Computational properties of use biological organisms or to the construction computers can emerge as collective systems having a large number simple equivalent components (or neurons). The physical meaning content-addressable ...

Language: Английский

Single-nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling DOI Creative Commons
K. Grace Foley, Mazhar Adli,

J. Julie Kim

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(34)

Published: Aug. 12, 2024

Significant racial disparities exist between Black and White patients with uterine serous carcinoma (USC). While the reasons for these are unclear, several studies have demonstrated significantly different rates of driver mutations groups, including TP53. However, limited research has investigated transcriptional differences tumors or composition tumor microenvironment (TME) groups. Here, we report single-nuclei RNA-sequencing profiles primary USC from diverse backgrounds. We find that there significant patients. Tumors exhibited higher expression specific genes associated aggressiveness, such as PAX8, axon guidance synaptic signaling pathways. also T cell populations reduced in tissue compared to matched benign, while anti-inflammatory macrophage retained within TME. Furthermore, connection PAX8 overexpression immunosuppression through regulation cytokines chemokines. Notably, show activity can influence gene protein secretion. These provide a detailed understanding transcriptome TME, identify biology

Language: Английский

Citations

3
Contextualizing racial associations in gene expression in patients with uterine serous carcinoma DOI Creative Commons
F. Rollin,

Shree A. Patel,

Samuel S. McCachren

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)

Published: Oct. 14, 2024

Computational properties of use biological organisms or to the construction computers can emerge as collective systems having a large number simple equivalent components (or neurons). The physical meaning content-addressable ...

Language: Английский

Citations

1
Reply to Rollin et al.: Clarifying the multifactorial origins of racial disparities in uterine serous carcinoma DOI Creative Commons
Julie Kim, Michael A. Simon, Gini F. Fleming

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(43)

Published: Oct. 14, 2024

Computational properties of use biological organisms or to the construction computers can emerge as collective systems having a large number simple equivalent components (or neurons). The physical meaning content-addressable ...

Language: Английский

Citations

0