Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103578 - 103578

Published: March 1, 2025

Cognitive impairment resulting from insufficient sleep poses a significant public health concern, particularly in children. The effects and mechanisms of choline on cognitive caused by deprivation are unknown. Chronic is induced young mice this study, followed feeding diet containing 11.36 g/kg bitartrate. Choline supplementation significantly improves spatial learning ability. Functional MRI results reveal the hippocampus as key region affected deprivation, where notably preserves hippocampal structural integrity enhanced connectivity. Additionally, ameliorates pathological injury, reduces blood-brain barrier permeability serum brain injury biomarkers. also inflammation oxidative stress biomarkers, mitigates microglial activation hippocampus, which synaptic plasticity. A finding changes phospholipidomic profile along with function, total 313 phospholipid molecules identified. increases levels sub-classes (particularly PC), strongly correlated reduced neuroinflammation well improved outcomes. Furthermore, there similar findings some such PC 36:1, O-33:0, p-38:3, PE 36:3, p-42:4 PS 44:12. These highlight that alleviates via reducing altering profile. This study suggests could develop into functional food or medicine ingredient to prevent treat disturbances, children adolescents.

Language: Английский

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Calcineurin goes to sleep

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(10)

Published: March 3, 2025

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Postnatal sleep restriction in male mice impairs the development of parvalbumin-positive neurons in the prefrontal cortex and increases anxiety-like behaviour

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Neuronal morphogenesis depends on extracellular guidance cues accurately instructing intracellular cytoskeletal remodeling. Here, we describe a novel role for the actin binding protein Coronin 1A (Coro1A) in neuronal morphogenesis, where it mediates responses to axon cue netrin-1. We found that Coro1A localizes growth cones and filopodial structures is required netrindependent turning, branching, corpus callosum development. previously discovered interacts with TRIM67, brain enriched E3 ubiquitin ligase netrin receptor also netrin-mediated morphogenesis. Loss of loss TRIM67 shared similar phenotypes, suggesting they may function together same pathway. A mutant deficient was not able rescue indicating interaction between responses. Together, our findings reveal proper collaborates downstream netrin.

Language: Английский

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Latent mechanisms of plasticity are upregulated during sleep

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 93, P. 103029 - 103029

Published: April 22, 2025

Language: Английский

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Sleep; noncoding regions of the genome; changing rates of U.S.-based autism diagnoses

The Transmitter, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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