R-loops in neurodegeneration DOI Creative Commons
Chiara Beghè,

Helena Harpham,

Yasmine Barberic

et al.

Current Opinion in Genetics & Development, Journal Year: 2025, Volume and Issue: 92, P. 102345 - 102345

Published: April 8, 2025

Neurodegenerative diseases are associated with the progressive loss of neurons. R-loops non-canonical nucleic acid structures formed during transcription and composed an RNA/DNA hybrid a displaced single-stranded DNA. Whilst important regulators cellular processes, they also pathologies multiple disorders, including repeat expansion, motor neuron, inflammatory ageing diseases. In this review, we discuss how contribute to pathological mechanisms that underpin neurodegeneration. We highlight role in several hallmarks neurodegenerative RNA DNA defects, damage, protein aggregation, inflammation, mitochondrial dysfunction, neuronal cell death. potential as therapeutic targets for disorders.

Language: Английский

3A or not 3A: Cytidine deaminases in the etiology of the CAG-repeat expansion diseases DOI Creative Commons
Karen Usdin

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(9)

Published: Feb. 24, 2025

Language: Английский

Citations

0
R-loops in neurodegeneration DOI Creative Commons
Chiara Beghè,

Helena Harpham,

Yasmine Barberic

et al.

Current Opinion in Genetics & Development, Journal Year: 2025, Volume and Issue: 92, P. 102345 - 102345

Published: April 8, 2025

Neurodegenerative diseases are associated with the progressive loss of neurons. R-loops non-canonical nucleic acid structures formed during transcription and composed an RNA/DNA hybrid a displaced single-stranded DNA. Whilst important regulators cellular processes, they also pathologies multiple disorders, including repeat expansion, motor neuron, inflammatory ageing diseases. In this review, we discuss how contribute to pathological mechanisms that underpin neurodegeneration. We highlight role in several hallmarks neurodegenerative RNA DNA defects, damage, protein aggregation, inflammation, mitochondrial dysfunction, neuronal cell death. potential as therapeutic targets for disorders.

Language: Английский

Citations

0