Genetic Diversity and Molecular Evolution of Hepatitis E Virus Within the Genus Chirohepevirus in Bats DOI Creative Commons
Bo Wang,

Peter Cronin,

Marcus G. Mah

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 339 - 339

Published: Feb. 28, 2025

Hepatitis E virus (HEV) is a major zoonotic pathogen causing hepatitis E, with strains identified in various animal species, including pigs, wild boar, rabbits, deer, camels, and rats. These variants are capable of crossing species barriers infecting humans. HEV belongs to the family Hepeviridae, which has recently divided into two subfamilies: Orthohepevirinae Parahepevirinae, five genera: Paslahepevirus, Avihepevirus, Rocahepevirus, Chirohepevirus, Piscihepevirus. Recent advances high-throughput sequencing, particularly bat viromes, have revealed numerous HEV-related viruses, raising concerns about their potential. Bat-derived HEVs been classified genus includes three distinct species. In this study, we analyzed 64 chirohepevirus sequences from 22 across six families collected nine countries. Twelve represent complete or nearly viral genomes (>6410 nucleotides) containing characteristic open reading frames (ORFs). exhibited high sequence divergence (>25%) within respective host genera Phylogenetic analyses maximum likelihood methods at least seven subclades each potentially representing an independent Additionally, close phylogenetic relationship between hosts indicates pattern virus–host co-speciation. Our findings expand known diversity Hepeviridae provide new insights evolution bat-associated HEV. Continued surveillance will be essential for understanding its potential transmission public health risks.

Language: Английский

Genetic Diversity and Molecular Evolution of Hepatitis E Virus Within the Genus Chirohepevirus in Bats DOI Creative Commons
Bo Wang,

Peter Cronin,

Marcus G. Mah

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 339 - 339

Published: Feb. 28, 2025

Hepatitis E virus (HEV) is a major zoonotic pathogen causing hepatitis E, with strains identified in various animal species, including pigs, wild boar, rabbits, deer, camels, and rats. These variants are capable of crossing species barriers infecting humans. HEV belongs to the family Hepeviridae, which has recently divided into two subfamilies: Orthohepevirinae Parahepevirinae, five genera: Paslahepevirus, Avihepevirus, Rocahepevirus, Chirohepevirus, Piscihepevirus. Recent advances high-throughput sequencing, particularly bat viromes, have revealed numerous HEV-related viruses, raising concerns about their potential. Bat-derived HEVs been classified genus includes three distinct species. In this study, we analyzed 64 chirohepevirus sequences from 22 across six families collected nine countries. Twelve represent complete or nearly viral genomes (>6410 nucleotides) containing characteristic open reading frames (ORFs). exhibited high sequence divergence (>25%) within respective host genera Phylogenetic analyses maximum likelihood methods at least seven subclades each potentially representing an independent Additionally, close phylogenetic relationship between hosts indicates pattern virus–host co-speciation. Our findings expand known diversity Hepeviridae provide new insights evolution bat-associated HEV. Continued surveillance will be essential for understanding its potential transmission public health risks.

Language: Английский

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