Tutorial on integrative spatiotemporal modeling by integrative modeling platform DOI Open Access
Andrew P. Latham,

Miha Rožič,

Benjamin Webb

et al.

Protein Science, Journal Year: 2025, Volume and Issue: 34(4)

Published: March 25, 2025

Cells function through dynamic interactions between macromolecules. Detailed characterization of the dynamics large biomolecular systems is often not feasible by individual biophysical methods. In such cases, it may be possible to compute useful models integrating multiple sources information. We have previously developed an integrative method model processes computing heterogeneity at fixed time points, then generating static structural modes for each these models, and finally connecting produce a scored trajectory that depicts process. Here, we demonstrate how compute, score, assess spatiotemporal using our open-source Integrative Modeling Platform (IMP) program (https://integrativemodeling.org/).

Language: Английский

Tutorial on integrative spatiotemporal modeling by integrative modeling platform DOI Open Access
Andrew P. Latham,

Miha Rožič,

Benjamin Webb

et al.

Protein Science, Journal Year: 2025, Volume and Issue: 34(4)

Published: March 25, 2025

Cells function through dynamic interactions between macromolecules. Detailed characterization of the dynamics large biomolecular systems is often not feasible by individual biophysical methods. In such cases, it may be possible to compute useful models integrating multiple sources information. We have previously developed an integrative method model processes computing heterogeneity at fixed time points, then generating static structural modes for each these models, and finally connecting produce a scored trajectory that depicts process. Here, we demonstrate how compute, score, assess spatiotemporal using our open-source Integrative Modeling Platform (IMP) program (https://integrativemodeling.org/).

Language: Английский

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