Distinct Bomanins at theDrosophila 55Clocus function in resistance and resilience to infections DOI Creative Commons
Yanyan Lou,

Bo Zhang,

Zhiyuan Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Host defense against many Gram-positive bacteria and fungal pathogens is mainly provided by the Toll-dependent systemic immune response in Drosophila . While antimicrobial peptides active these categories of contribute only modestly to protection, Bomanin are major effectors Toll pathway. Remarkably, flies deleted for 55C locus that contains 10 genes as sensitive pathway mutant infections. Yet, exact functions single Bomanins resistance or resilience infections remain poorly characterized. Here, we have extensively studied role genes. BomT1 Enterococcus faecalis while playing a Metarhizium robertsii infection, like BomS2. BomT2 prevent dissemination Candida albicans throughout host, even though they not sufficient confer protection immunodeficient this pathogen survival experiments. Furthermore, BomBc1 mutants an Aspergillus fumigatus ribotoxin. We conclude defined albeit sometimes overlapping roles different facets host

Language: Английский

Fungal effector disables cathepsin-driven Toll immunity in insects DOI Creative Commons
Rebecca J. Tay, Yen‐Ping Hsueh

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(8)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Distinct Bomanins at theDrosophila 55Clocus function in resistance and resilience to infections DOI Creative Commons
Yanyan Lou,

Bo Zhang,

Zhiyuan Zhang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Host defense against many Gram-positive bacteria and fungal pathogens is mainly provided by the Toll-dependent systemic immune response in Drosophila . While antimicrobial peptides active these categories of contribute only modestly to protection, Bomanin are major effectors Toll pathway. Remarkably, flies deleted for 55C locus that contains 10 genes as sensitive pathway mutant infections. Yet, exact functions single Bomanins resistance or resilience infections remain poorly characterized. Here, we have extensively studied role genes. BomT1 Enterococcus faecalis while playing a Metarhizium robertsii infection, like BomS2. BomT2 prevent dissemination Candida albicans throughout host, even though they not sufficient confer protection immunodeficient this pathogen survival experiments. Furthermore, BomBc1 mutants an Aspergillus fumigatus ribotoxin. We conclude defined albeit sometimes overlapping roles different facets host

Language: Английский

Citations

0