Cross-Kingdom DNA Methylation Dynamics: Comparative Mechanisms of 5mC/6mA Regulation and Their Implications in Epigenetic Disorders DOI Creative Commons
Yu Liu, Ying Wang, Dapeng Bao

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 461 - 461

Published: April 24, 2025

DNA methylation, a cornerstone of epigenetic regulation, governs critical biological processes including transcriptional modulation, genomic imprinting, and transposon suppression through chromatin architecture remodeling. Recent advances have revealed that aberrant methylation patterns—characterized by spatial-temporal dysregulation stochastic molecular noise—serve as key drivers diverse pathological conditions, from oncogenesis to neurodegenerative disorders. However, the field faces dual challenges: (1) current understanding remains fragmented due inherent spatiotemporal heterogeneity landscapes across tissues developmental stages, (2) mechanistic insights into non-canonical pathways (particularly 6mA) in non-mammalian systems are conspicuously underdeveloped. This review systematically synthesizes evolutionary-conserved versus species-specific features 5-methylcytosine (5mC) N6-methyladenine (6mA) regulatory networks three kingdoms. Through comparative analysis methylation/demethylation enzymatic cascades (DNMTs/TETs mammals, CMTs/ROS1 plants, DIM-2/DNMTA fungi), we propose unified framework for targeting methylation-associated diseases precision epigenome editing, while identifying knowledge gaps fungal methylome engineering demand urgent investigation.

Language: Английский

Cross-Kingdom DNA Methylation Dynamics: Comparative Mechanisms of 5mC/6mA Regulation and Their Implications in Epigenetic Disorders DOI Creative Commons
Yu Liu, Ying Wang, Dapeng Bao

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 461 - 461

Published: April 24, 2025

DNA methylation, a cornerstone of epigenetic regulation, governs critical biological processes including transcriptional modulation, genomic imprinting, and transposon suppression through chromatin architecture remodeling. Recent advances have revealed that aberrant methylation patterns—characterized by spatial-temporal dysregulation stochastic molecular noise—serve as key drivers diverse pathological conditions, from oncogenesis to neurodegenerative disorders. However, the field faces dual challenges: (1) current understanding remains fragmented due inherent spatiotemporal heterogeneity landscapes across tissues developmental stages, (2) mechanistic insights into non-canonical pathways (particularly 6mA) in non-mammalian systems are conspicuously underdeveloped. This review systematically synthesizes evolutionary-conserved versus species-specific features 5-methylcytosine (5mC) N6-methyladenine (6mA) regulatory networks three kingdoms. Through comparative analysis methylation/demethylation enzymatic cascades (DNMTs/TETs mammals, CMTs/ROS1 plants, DIM-2/DNMTA fungi), we propose unified framework for targeting methylation-associated diseases precision epigenome editing, while identifying knowledge gaps fungal methylome engineering demand urgent investigation.

Language: Английский

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