Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives DOI Creative Commons
David Llères,

A. Gizzi,

Marcelo Nöllmann

et al.

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 95, P. 102527 - 102527

Published: May 16, 2025

This review explores recent emerging insights into enhancer action, focusing on underexplored aspects such as the physical size of regulatory elements, stochasticity transcription factor binding and chromatin structure, role nonlinear processes in reconciling longstanding discrepancies between theoretical models experimental observations. Together, these provide a nuanced view biology, highlighting complexity gene regulation need for innovative methodologies to further decode mechanisms.

Language: Английский

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives DOI Creative Commons
David Llères,

A. Gizzi,

Marcelo Nöllmann

et al.

Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 95, P. 102527 - 102527

Published: May 16, 2025

This review explores recent emerging insights into enhancer action, focusing on underexplored aspects such as the physical size of regulatory elements, stochasticity transcription factor binding and chromatin structure, role nonlinear processes in reconciling longstanding discrepancies between theoretical models experimental observations. Together, these provide a nuanced view biology, highlighting complexity gene regulation need for innovative methodologies to further decode mechanisms.

Language: Английский

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