Progress and prospect of polysaccharides as adjuvants in vaccine development DOI Creative Commons
Xiaoping Liang, Jianshe Zhou, Mengmeng Wang

et al.

Virulence, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Vaccines are an effective approach to confer immunity against infectious diseases. Modern subunit vaccines offer more precise target and safe protection compared traditional whole-pathogen vaccines. However, require adjuvants stimulate the immune system due less immunogenicity. Adjuvants strengthen immunogenicity by enhancing, modulating, prolonging response. Unfortunately, few have sufficient potency low enough toxicity for clinical use, highlighting urgent need new vaccine with characteristics of safety, efficacy, cost-effectiveness. Notably, some natural polysaccharides been approved as in human vaccines, owing their intrinsic immunomodulation, toxicity, high safety. Natural mainly derived from plants, bacteria, yeast. Partly difficulty obtaining them, synthetic emerged trials. The mechanisms both remain incompletely understood, hindering rational development polysaccharide adjuvants. This comprehensive review primarily focused on several promising adjuvants, discussing recent applications immune-modulatory effects. Furthermore, future perspectives insightful guidance adjuvant application.

Language: Английский

Progress and prospect of polysaccharides as adjuvants in vaccine development DOI Creative Commons
Xiaoping Liang, Jianshe Zhou, Mengmeng Wang

et al.

Virulence, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Vaccines are an effective approach to confer immunity against infectious diseases. Modern subunit vaccines offer more precise target and safe protection compared traditional whole-pathogen vaccines. However, require adjuvants stimulate the immune system due less immunogenicity. Adjuvants strengthen immunogenicity by enhancing, modulating, prolonging response. Unfortunately, few have sufficient potency low enough toxicity for clinical use, highlighting urgent need new vaccine with characteristics of safety, efficacy, cost-effectiveness. Notably, some natural polysaccharides been approved as in human vaccines, owing their intrinsic immunomodulation, toxicity, high safety. Natural mainly derived from plants, bacteria, yeast. Partly difficulty obtaining them, synthetic emerged trials. The mechanisms both remain incompletely understood, hindering rational development polysaccharide adjuvants. This comprehensive review primarily focused on several promising adjuvants, discussing recent applications immune-modulatory effects. Furthermore, future perspectives insightful guidance adjuvant application.

Language: Английский

Citations

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