Biomedical Materials, Journal Year: 2024, Volume and Issue: 20(1), P. 015030 - 015030

Published: Dec. 20, 2024

Abstract Psidium guajava L. (Myrtaceae) has long been used in folk medicine as a potent therapeutic agent for the treatment of inflammation. Despite its potential, application this natural source remains limited because instability and poor permeability through biological barriers. Among different available strategies, niosomes, surfactant-based nanovesicular system, may help maximize plant extract. Indeed, nanosystem represents several advantages drug delivery such improved bioavailability, reduced toxicity, better stability, possible targeting controlled release, biocompatability, biodegradability. The aim study was to develop optimize formulation niosomal system encapsulating guava leaf extract (GLs-N) anti-inflammatory applications. niosomes were fabricated using ethanol injection method optimized terms surfactant, cholesterol, GLs content an experimental design model. finalized physicochemically characterized tested their encapsulation efficiency (EE), permeability, vitro vivo activities zebrafish As result, 167.9 ± 1.845 nm size, with PDI 0.212 0.005, negatively charged, EE 65.54%. Compared free GLs, GLs-niosomes presented significant increase possessed good stability over 28 d at both 4 °C 25 °C. Most importantly, studies confirmed that activity much stronger than 4.2 fold ibuprofen. Collectively, successful developing optimizing structure effective wild GL

Language: Английский