Antigenic switch potential of influenza D virus DOI Creative Commons
Abdul Bari Hejran,

Khaidarov Saken,

Rahmatullah Afghan

et al.

Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The antigenic variability of Influenza D virus (IDV), a recently identified pathogen with significant implications for livestock and zoonotic diseases, presents unique challenges in virology, epidemiology, public health. This review stands out by focusing explicitly on IDV's distinct shift drift mechanisms, which are underexplored compared to other influenza viruses. Unlike previous studies that broadly address evolution, this research emphasizes IDV’s specific molecular ecological traits, particularly its hemagglutinin-esterase fusion (HEF) protein, plays critical role reconfiguration. study integrates genomic sequencing, structural bioinformatics, epidemiological surveillance deliver comprehensive understanding evolutionary potential cross-species transmission risks. uniquely highlights moderate propensity switching, reservoirs such as cattle swine, act amplification hosts viral dissemination. By rigorously mapping the virus’s architecture, work provides novel insights into adaptive mechanisms trajectory, offering practical vaccine development, immune evasion strategies, interspecies control. methodological foundation includes an exhaustive peer-reviewed literature, silico simulations, phylogenetic analyses, setting apart detailed exploration dynamics. Findings emphasize posed IDV sustainable necessitating regular updates ongoing shifts. significantly advances global efforts understand manage underscoring urgent need enhanced agricultural, veterinary, health systems. doing so, it bridges knowledge gaps informs future diagnostic, therapeutic, preventive strategies tailored mitigate threats.

Language: Английский

Antigenic switch potential of influenza D virus DOI Creative Commons
Abdul Bari Hejran,

Khaidarov Saken,

Rahmatullah Afghan

et al.

Asia-Pacific Journal of Pharmacotherapy & Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

The antigenic variability of Influenza D virus (IDV), a recently identified pathogen with significant implications for livestock and zoonotic diseases, presents unique challenges in virology, epidemiology, public health. This review stands out by focusing explicitly on IDV's distinct shift drift mechanisms, which are underexplored compared to other influenza viruses. Unlike previous studies that broadly address evolution, this research emphasizes IDV’s specific molecular ecological traits, particularly its hemagglutinin-esterase fusion (HEF) protein, plays critical role reconfiguration. study integrates genomic sequencing, structural bioinformatics, epidemiological surveillance deliver comprehensive understanding evolutionary potential cross-species transmission risks. uniquely highlights moderate propensity switching, reservoirs such as cattle swine, act amplification hosts viral dissemination. By rigorously mapping the virus’s architecture, work provides novel insights into adaptive mechanisms trajectory, offering practical vaccine development, immune evasion strategies, interspecies control. methodological foundation includes an exhaustive peer-reviewed literature, silico simulations, phylogenetic analyses, setting apart detailed exploration dynamics. Findings emphasize posed IDV sustainable necessitating regular updates ongoing shifts. significantly advances global efforts understand manage underscoring urgent need enhanced agricultural, veterinary, health systems. doing so, it bridges knowledge gaps informs future diagnostic, therapeutic, preventive strategies tailored mitigate threats.

Language: Английский

Citations

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