MR‐Cavitation Dynamics Encoded (MR‐CaDE) imaging DOI Creative Commons
Dinank Gupta, Tarana Parvez Kaovasia, Steven P. Allen

et al.

Magnetic Resonance in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Purpose To develop methods for dynamic cavitation monitoring of a non‐invasive ultrasound mechanical ablation technology (histotripsy) in the brain and test its feasibility treatment ex‐vivo human MRI scanner. Methods A Gradient Echo (GRE) pulse sequence was modified with bipolar gradient to perform MR‐Cavitation Dynamics Encoded (MR‐CaDE) imaging. Cavitation generated by histotripsy sonication monitored using MR‐CaDE imaging bovine tissues on Bipolar gradients b‐value smaller were used while trigger sent from MR scanner driving electronics. acquisition performed TE/TR: 1.5‐cycle sonications at 1 pulse/TR. Feasibility also evaluated through an excised skull. Results The temporal resolution spiral readout. decrease image magnitude increase phase observed increasing number sonications. exhibited peak loss 50%, maximum 0.64rad compared baseline signal level brain. change aligned well array's geometrical focus, post‐histotripsy lesion visualized DWI () scan alignment error transverse longitudinal axes, respectively. area response readout images , Conclusion This work demonstrated sequence, which can be monitor events histotripsy.

Language: Английский

MR‐Cavitation Dynamics Encoded (MR‐CaDE) imaging DOI Creative Commons
Dinank Gupta, Tarana Parvez Kaovasia, Steven P. Allen

et al.

Magnetic Resonance in Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Purpose To develop methods for dynamic cavitation monitoring of a non‐invasive ultrasound mechanical ablation technology (histotripsy) in the brain and test its feasibility treatment ex‐vivo human MRI scanner. Methods A Gradient Echo (GRE) pulse sequence was modified with bipolar gradient to perform MR‐Cavitation Dynamics Encoded (MR‐CaDE) imaging. Cavitation generated by histotripsy sonication monitored using MR‐CaDE imaging bovine tissues on Bipolar gradients b‐value smaller were used while trigger sent from MR scanner driving electronics. acquisition performed TE/TR: 1.5‐cycle sonications at 1 pulse/TR. Feasibility also evaluated through an excised skull. Results The temporal resolution spiral readout. decrease image magnitude increase phase observed increasing number sonications. exhibited peak loss 50%, maximum 0.64rad compared baseline signal level brain. change aligned well array's geometrical focus, post‐histotripsy lesion visualized DWI () scan alignment error transverse longitudinal axes, respectively. area response readout images , Conclusion This work demonstrated sequence, which can be monitor events histotripsy.

Language: Английский

Citations

0