Multifaceted roles of mitochondria in asthma DOI Creative Commons
Wei Zhang, Chen‐Yu Zhang, Yi Zhang

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Oct. 9, 2024

Mitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differentiation, growth, apoptosis, energy conversion, metabolism, and immunity. The phenotypic variation of mitochondria is specific to different tissues cell types, resulting significant differences their function, morphology, molecular characteristics. Asthma a chronic, complex, heterogeneous airway disease influenced by external factors such as environmental pollutants allergen exposure, well internal at the tissue, cellular, genetic levels, lung structural immune granulocytes, mast cells. Therefore, comprehensive understanding responses stimuli changes crucial for elucidating pathogenesis asthma. Previous research on mitochondrial-targeted therapy asthma has primarily focused antioxidants. Consequently, it necessary summarize multifaceted discover additional strategies targeting this context. In review, our goal describe mitochondrial function response exposure across types other relevant context asthma, utilizing new terminology framework that encompasses cell-dependent characteristics, features, activity, behavior.

Language: Английский

Multifaceted roles of mitochondria in asthma DOI Creative Commons
Wei Zhang, Chen‐Yu Zhang, Yi Zhang

et al.

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Oct. 9, 2024

Mitochondria are essential organelles within cells, playing various roles in numerous cellular processes, including differentiation, growth, apoptosis, energy conversion, metabolism, and immunity. The phenotypic variation of mitochondria is specific to different tissues cell types, resulting significant differences their function, morphology, molecular characteristics. Asthma a chronic, complex, heterogeneous airway disease influenced by external factors such as environmental pollutants allergen exposure, well internal at the tissue, cellular, genetic levels, lung structural immune granulocytes, mast cells. Therefore, comprehensive understanding responses stimuli changes crucial for elucidating pathogenesis asthma. Previous research on mitochondrial-targeted therapy asthma has primarily focused antioxidants. Consequently, it necessary summarize multifaceted discover additional strategies targeting this context. In review, our goal describe mitochondrial function response exposure across types other relevant context asthma, utilizing new terminology framework that encompasses cell-dependent characteristics, features, activity, behavior.

Language: Английский

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