The Pharmaceutical and Pharmacological Potential Applications of Bilosomes as Nanocarriers for Drug Delivery

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1181 - 1181

Published: March 6, 2025

Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.

Language: Английский

A Comprehensive Review on Current Knowledge and Future Potential of Topical Therapies in Breast Cancer Treatment

Meme sağlığı dergisi/Meme sağlığı dergisi, Journal Year: 2025, Volume and Issue: 21(1), P. 9 - 15

Published: Jan. 2, 2025

Key Points •Topical therapies are localized treatments that target the breast tumour location specifically.• By limiting drug's exposure to rest of body, this strategy lowers possibility systemic adverse effects. •The efficacy therapy may be increased by direct application location.• These function directly targeting cancer cells through skin penetration, which can help minimise size and relieve symptoms.• To increase overall effectiveness treatment, topical frequently used in conjunction with other including radiation, surgery, or chemotherapy.

Language: Английский

Vesicular Nanosystem as a Promising Platform for the Management of Cancer

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский