MXene-encapsulated ZIF-8@Liposomes for NIR-enhanced photothermal therapy in hepatocellular carcinoma treatment: In vitro, in vivo, and in silico study DOI
Shehab Elbeltagi, Nawal Madkhali, Hanan M. Alharbi

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 764, P. 110256 - 110256

Published: Dec. 6, 2024

Language: Английский

Enhanced chemo-photothermal therapy using cisplatin-loaded MXene nanosheets conjugated with Z(BTC) for effective HepG2 cancer treatment DOI

Arwa Sultan Alqahtani,

Amirah S. Alahmari,

Zienab E. Eldin

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114128 - 114128

Published: Feb. 1, 2025

Language: Английский

Citations

1
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment DOI
Zainab Lafi, Sina M. Matalqah,

Ebaa Abu-Saleem

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 9, 2024

Language: Английский

Citations

4
Preformulation studies and in vitro cytotoxicity of naringin DOI

Agustina Gaitán,

Soledad Ravetti, Ariel G. Garro

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: Feb. 24, 2025

This study evaluates the chemical and enzymatic stability of naringin (NRG), identifies its degradation metabolites, assesses in vitro cytotoxicity, validates a high-performance liquid chromatography (HPLC) method for precise quantification. NRG, flavonoid with antioxidant, anti-inflammatory, anticancer properties, faces clinical limitations due to poor solubility, rapid degradation, low bioavailability. While research efforts on this promising compound have largely focused overcoming these through formulation strategies, it is equally necessary complementary focus preformulation studies enhance NRG's therapeutic potential. These represent fundamental step drug development, providing key insights into physicochemical biological properties NRG serving as basis rational design safe effective formulations future research. was analyzed under various temperature pH conditions. Cytotoxicity evaluated 3T3 cells, an HPLC developed validated quantify primary metabolite, naringenin (NRGN). remained stable up 100 °C physiological (1.2, 5.8, 7.4) but degraded at extreme pH, forming NRGN. assays showed toxicity ≤1 mM (viability >80%), whereas 5 significantly reduced viability. The exhibited high precision, specificity, accuracy distinguishing from provides critical stability, safety, quantification, supporting potential development. findings establish foundation aimed enhancing bioavailability applicability.

Language: Английский

Citations

0
Multifunctional sorafenib-loaded MXene for enhanced cancer therapy: In vitro and in vivo study based on chemotherapy/photothermal therapy approach DOI
Shehab Elbeltagi, Mohammed Al‐Zharani, Fahd A. Nasr

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125492 - 125492

Published: March 1, 2025

Language: Английский

Citations

0
A review on integrated design and application of stimuli-responsive ZIF-8 metal-organic frameworks for breast cancer theranostics DOI
Abhishek Jha, Sanchit Arora,

Rohan Chand Sahu

et al.

Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100611 - 100611

Published: March 22, 2025

Language: Английский

Citations

0
Enhanced therapeutic efficacy of platinum-doxorubicin nanoparticles on colon and breast cancer cell lines DOI Creative Commons
Ferdane Danışman Kalındemirtaş,

Gökçe Erdemir Cilasun,

İshak Afşin Kari̇per

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

0
A novel zingerone-loaded zinc MOF coated by niosome nanocomposites to enhance antimicrobial properties and apoptosis in breast cancer cells DOI
Hanan M. Alharbi, Abdel‐Nasser M.A. Alaghaz,

Tayel A. Al Hujran

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 41, P. 110245 - 110245

Published: Aug. 28, 2024

Language: Английский

Citations

3
MXene-encapsulated ZIF-8@Liposomes for NIR-enhanced photothermal therapy in hepatocellular carcinoma treatment: In vitro, in vivo, and in silico study DOI
Shehab Elbeltagi, Nawal Madkhali, Hanan M. Alharbi

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 764, P. 110256 - 110256

Published: Dec. 6, 2024

Language: Английский

Citations

3