Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends
Drug Development and Industrial Pharmacy,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: March 21, 2025
This
review
examines
recent
advancements
in
nanoparticle-based
delivery
systems
for
phytochemicals,
focusing
on
their
role
overcoming
multidrug
resistance,
improving
therapeutic
efficacy,
and
facilitating
clinical
translation.
highlights
advances
nanoparticle-enabled
phytochemical
to
enhance
bioavailability,
improve
outcomes,
enable
targeted
applications.
By
comparing
various
nanoparticle
systems,
formulation
methods,
efficacy
data,
it
identifies
gaps
current
research
guides
the
development
of
more
effective,
next-generation
phytochemical-loaded
nanocarriers.
A
systematic
literature
published
between
2000
2024
was
conducted
using
PubMed,
Scopus,
Web
Science.
Articles
cancer
therapy
were
included.
Compounds
such
as
curcumin,
resveratrol,
quercetin,
epigallocatechin
gallate
demonstrate
enhanced
anti-cancer
when
encapsulated
nanoparticles,
leading
improved
increased
tumor
cell
targeting,
reduced
toxicity.
Clinical
trials
indicate
regression
fewer
adverse
effects.
Emerging
approaches-such
nanogels,
hybrid
combination
therapies
with
immune
checkpoint
inhibitors-further
refine
treatment
efficacy.
Nanoparticle-based
significantly
potential
making
them
promising
candidates
safer,
effective
treatments.
However,
challenges
related
regulatory
guidelines,
scalability,
long-term
safety
must
be
addressed
fully
realize
potential.
Language: Английский
Revolutionizing Oncology: Iron Oxide Nanoparticles in Cancer Diagnosis and Treatment
International Journal of Scientific Research in Science and Technology,
Journal Year:
2025,
Volume and Issue:
12(1), P. 161 - 173
Published: Jan. 26, 2025
Iron
oxide
nanoparticles
(IONPs)
have
emerged
as
a
transformative
tool
in
oncology,
offering
unprecedented
opportunities
for
early
cancer
diagnosis
and
effective
treatment.
These
exhibit
unique
physicochemical
properties,
including
superparamagnetism,
biocompatibility,
large
surface
area-to-volume
ratio.
properties
make
them
particularly
suitable
applications
such
high-resolution
imaging,
targeted
drug
delivery,
hyperthermia
therapy.
Additionally,
their
ability
to
be
functionalized
with
various
biomolecules
enables
precision
targeting
of
cancerous
tissues,
further
enhancing
efficacy.
This
article
delves
into
the
cutting-edge
advancements
utilization
IONPs,
examines
multifunctional
roles
addresses
challenges
clinical
translation,
outlines
future
directions
research
application
this
dynamic
field.
Language: Английский