An independent biosynthetic route to frame a xanthanolide‐type sesquiterpene lactone in Asteraceae DOI
Changfu Li, Yuanjun Li, J Wang

et al.

The Plant Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

SUMMARY Xanthanolides, also described as seco‐guaianolides, are unique sesquiterpene lactones (STLs) with diverse bioactivities. Most of xanthanolides 12,8‐olides based on the position their lactone ring. The biosynthetic pathway leading to has hitherto been elusive, especially how nature creates xanthane skeleton is a long‐standing question. This study reports elucidation complete important 12,8‐xanthanolide 8‐ epi ‐xanthatin. xanthane‐type backbone directly derived from central precursor germacrene‐type sesquiterpene, germacrene A acid, via oxidative rearrangement, catalyzed by an unusual cytochrome P450. Subsequently, 12,8‐lactone ring formed within this resulting in xanthanolides. for contrasts previously unified route 12,6‐guaianolides, which 12,6‐lactone formation precedes transformation into guaiane‐type structure. discovery full ‐xanthantin opens new opportunities producing microbial organisms using synthetic biology strategies.

Language: Английский

Plant specialized metabolism: Diversity of terpene synthases and their products DOI
Matthew E. Bergman, Natalia Dudareva

Current Opinion in Plant Biology, Journal Year: 2024, Volume and Issue: 81, P. 102607 - 102607

Published: July 24, 2024

Language: Английский

Citations

7
Harnessing the Transcriptomic Resources of Millets to Decipher Climate Resilience and Nutrient Enrichment Traits DOI
Theivanayagam Maharajan, Stanislaus Antony Ceasar,

Thumadath Palayullaparambil Ajeesh Krishna

et al.

Critical Reviews in Plant Sciences, Journal Year: 2024, Volume and Issue: 43(5), P. 348 - 375

Published: June 1, 2024

Rich nutrients, climate resilience, and the economic importance of millets are believed to ensure food security for future generations. Millets have habit growing against abiotic stresses (particularly drought stress). show much better resilience nutrient supplementation properties compared other major cereals. Understanding molecular mechanisms genes that respond transport will help understand tolerance mechanism improve both stresses. Genome sequences currently available two (sorghum pearl millet) eight minor (foxtail millet, finger kodo barnyard proso job's tear, fonio tef). Five (little brown top guinea raishan) do not genome date. Transcriptome studies identify differentially expressed (DEGs), mine induced in a particular stress develop several markers all plants, including millets. Some reports on transcriptome datasets plants exposed various biotic nutritional traits. Unfortunately, been adequately leveraged explore associated with traits such as enrichment, crop improvement. This underutilization stems from lack high-resolution limited exploration within field. As result, potential insights genetic understanding offered by these remain largely untapped. Through this review, we plan elucidate current status resources draw utilization resources. review motivate researchers utilize millet

Language: Английский

Citations

5
Extraction of Essential Oils and Terpene Volatiles from Plants and Identification by GC-MS-Based Techniques DOI

Sandra T. Krause,

Maximilian Frey

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 73 - 82

Published: Jan. 1, 2025

Language: Английский

Citations

0
Investigating the therapeutic potential of terpene metabolites in hot-natured herbal medicines and their mechanistic impact on circulatory disorders DOI

Huong-Giang Le,

Thanh Hao Huynh,

Bo‐Rong Peng

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Protective Effect of Artemisinin Against Luperox Induced Oxidative Stress and Insulin Resistance via Pi3k/Akt Pathway in Zebrafish Larvae DOI
Kadhirmathiyan Velumani, Priyanka Rajan, Mohammed Rafi Shaik

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
Plant sesquiterpene lactones DOI

Olivia Agatha,

Daniela Mutwil‐Anderwald,

Jhing Yein Tan

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1914)

Published: Sept. 29, 2024

Sesquiterpene lactones (STLs) are a prominent group of plant secondary metabolites predominantly found in the Asteraceae family and have multiple ecological roles medicinal applications. This review describes evolutionary significance STLs, highlighting their defence mechanisms against herbivory as phytotoxins, alongside function environmental signalling molecules. We also cover substantial role STLs medicine mode action health disease. discuss biosynthetic pathways various modifications that make one most diverse groups metabolites. Finally, we methods for identifying predicting STL biosynthesis pathways. article is part theme issue ‘The evolution metabolism’.

Language: Английский

Citations

3
Antiparasitic Activity of Isolated Fractions from Parthenium incanum Kunth against the Hemoflagellate Protozoan Trypanosoma cruzi DOI Creative Commons
David Alejandro Hernández-Marín, Rocío Castro‐Ríos, Abelardo Chávez-Montes

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 622 - 622

Published: July 4, 2024

This study focused on isolating, identifying, and evaluating the trypanocidal potential against hemoflagellate protozoan

Language: Английский

Citations

2
Metabolite Profiles of Green Leaves and Coffee Beans as Predictors of Coffee Sensory Quality in Robusta (Coffea Canephora) Germplasm from the Democratic Republic of the Congo DOI
Robrecht Bollen, Olga Rojo-Poveda, Lauren Verleysen

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

2
Metabolite profiles of green leaves and coffee beans as predictors of coffee sensory quality in Robusta (Coffea canephora) germplasm from the Democratic Republic of the Congo DOI Creative Commons
Robrecht Bollen, Olga Rojo-Poveda, Lauren Verleysen

et al.

Applied Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 100560 - 100560

Published: Oct. 1, 2024

Language: Английский

Citations

1
An independent biosynthetic route to frame a xanthanolide‐type sesquiterpene lactone in Asteraceae DOI
Changfu Li, Yuanjun Li, J Wang

et al.

The Plant Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

SUMMARY Xanthanolides, also described as seco‐guaianolides, are unique sesquiterpene lactones (STLs) with diverse bioactivities. Most of xanthanolides 12,8‐olides based on the position their lactone ring. The biosynthetic pathway leading to has hitherto been elusive, especially how nature creates xanthane skeleton is a long‐standing question. This study reports elucidation complete important 12,8‐xanthanolide 8‐ epi ‐xanthatin. xanthane‐type backbone directly derived from central precursor germacrene‐type sesquiterpene, germacrene A acid, via oxidative rearrangement, catalyzed by an unusual cytochrome P450. Subsequently, 12,8‐lactone ring formed within this resulting in xanthanolides. for contrasts previously unified route 12,6‐guaianolides, which 12,6‐lactone formation precedes transformation into guaiane‐type structure. discovery full ‐xanthantin opens new opportunities producing microbial organisms using synthetic biology strategies.

Language: Английский

Citations

0