Mechanistic insights and therapeutic implications of novel pyrazoline derivatives on antioxidant and enzymatic inhibitory activities

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1296, P. 136761 - 136761

Published: Oct. 4, 2023

Language: Английский

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Exploring Juniperus phoenicea L extract through phytochemical analysis, anti-lipase effects, and comprehensive molecular studies

Process Biochemistry, Journal Year: 2024, Volume and Issue: 147, P. 152 - 164

Published: Aug. 27, 2024

Language: Английский

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In silico study of novel coumarin derivatives as potential agents in the pancreatic cancer treatment

Computer Methods in Biomechanics & Biomedical Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Nov. 20, 2024

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest diseases. Here are investigated two synthesized and hypothetical coumarin derivatives, their capacity to be used in PDAC targeted treatment. The inhibitory activity these four molecules against PARP, ATM, CHK1 proteins responsible for DNA molecule repair was examined by docking molecular dynamic analysis. ADMET analysis applied determine pharmacokinetic properties tested compounds. theoretical approach showed that biomedical coumarins comparable Olaparib, already

Language: Английский

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Design, Synthesis, enzyme inhibitory activity and molecular docking studies of new 1,2,3-triazole linked nucleobases

Results in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 102011 - 102011

Published: Dec. 1, 2024

Language: Английский

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