Caffeic acid, a dietary polyphenol pre-sensitizes PDAC to chemotherapeutic drug DOI Creative Commons
Shruti Gupta,

Harshita Tak,

Khushhal Rathore

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 18, 2023

Abstract Purpose: Resistance to chemotherapeutics is an eminent cause which leads for search of options that help in diminution Pancreatic Ductal Adenocarcinoma (PDAC) by overcoming resistance issues. Caffeic acid (CFA), a polyphenol occurring many dietary foods known show anti-diabetic and anticancer properties potential. Methods: To unveil effect CFA on PDAC we carried out this research cells, following checked combination pre-sensitization effects CFA. Multitudinous web-based approaches were applied identifying targets then getting their interconnections. Results conclusions: Subsequently, manifested affects in-vitro analysis showing IC 50 concentrations 37.37µM 15.06µM Panc-1 Mia-PaCa-2 respectively. Combination index with different drugs was explored gave no significant results leading further investigate pre-sensitizing effects. reduced concentration doxorubicin both cell lines also triggered ROS generation determined DCFH-DA assay. Gene expression revealed acts differently triggers distinct signalling overcome resistance. Collectively, study investigated role as therapeutics mechanism mitigating sensitizing chemotherapeutics.

Language: Английский

Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action DOI
Sarita Rani, Shruti Gupta,

Kiran Kumar Tejavath

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138809 - 138809

Published: Dec. 1, 2024

Language: Английский

Citations

0
Caffeic acid, a dietary polyphenol pre-sensitizes PDAC to chemotherapeutic drug DOI Creative Commons
Shruti Gupta,

Harshita Tak,

Khushhal Rathore

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 18, 2023

Abstract Purpose: Resistance to chemotherapeutics is an eminent cause which leads for search of options that help in diminution Pancreatic Ductal Adenocarcinoma (PDAC) by overcoming resistance issues. Caffeic acid (CFA), a polyphenol occurring many dietary foods known show anti-diabetic and anticancer properties potential. Methods: To unveil effect CFA on PDAC we carried out this research cells, following checked combination pre-sensitization effects CFA. Multitudinous web-based approaches were applied identifying targets then getting their interconnections. Results conclusions: Subsequently, manifested affects in-vitro analysis showing IC 50 concentrations 37.37µM 15.06µM Panc-1 Mia-PaCa-2 respectively. Combination index with different drugs was explored gave no significant results leading further investigate pre-sensitizing effects. reduced concentration doxorubicin both cell lines also triggered ROS generation determined DCFH-DA assay. Gene expression revealed acts differently triggers distinct signalling overcome resistance. Collectively, study investigated role as therapeutics mechanism mitigating sensitizing chemotherapeutics.

Language: Английский

Citations

1